Zwitterionic bottlebrush elastomers for bioelectronics

用于生物电子学的两性离子洗瓶刷弹性体

• 批准号: 576142-2022
• 负责人: Tran, HelenH
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748331
• 关键词: Zwitterionic; bottlebrush; elastomers; bioelectronics

Advances in implantable bioelectronics are changing our understanding and treatment of neurological disorders. For example, commercial ventures like Neuralink and Kernel are realizing ultra-high-bandwidth brain-machine interfaces with fiber-like flexible probes. Because chronic implantation is needed for lifelong disorders, it is important to consider strategies to mitigate the immunological responses that lead to device failure. One approach to improving tissue compatibility is to reduce the mechanical rigidity of devices by using low bending stiffness architectures or lower-modulus materials, but these efforts have not matched the moduli of soft biological tissue. Consider the softness of your lips to the electronics in your mobile phones-- you can intuitively discern a large difference in softness and stretchability. There have been advances in making electronic materials with a good mechanical match to biological tissue; one example is a class of material called hydrogels. However, hydrogels contain substantial water, which complicates electronic performance and device fabrication (e.g., it is difficult to adhere wet layers together). Also, there have been advances in making materials that are effectively stealth to our immune system through precise chemical functionalities, delaying and avoiding device failure. These materials are non-fouling or effectively mimic the natural milieu, avoiding the cascade of immunological events that leads to fibrotic capsule formation and device failure. However, chemical strategies alone are insufficient for long-term implantation of devices. Currently, an integrated materials platform that exploits both mechanical and chemical approaches does not exist and poses as a potential solution for extending implantation time. There work described herein is a collaborative effort between a chemist and physicist to synthesize ultrasoft materials that are non-fouling and subsequently characterize their mechanical properties to design the next generation of coatings for implantable devices.

植入式生物电子学的进步正在改变我们对神经系统疾病的理解和治疗。例如，像Neuralink和Kernel这样的商业企业正在用类似光纤的柔性探针实现超高带宽的脑机接口。由于终身疾病需要长期植入，因此重要的是考虑减轻导致器械失效的免疫反应的策略。改善组织相容性的一种方法是通过使用低弯曲刚度架构或低模量材料来降低装置的机械刚度，但这些努力并不匹配软生物组织的模量。想想你的嘴唇对移动的手机电子设备的柔软度--你可以直观地辨别出柔软度和伸展度的巨大差异。在制造与生物组织具有良好机械匹配的电子材料方面已经取得了进展;一个例子是一类称为水凝胶的材料。然而，水凝胶含有大量的水，这使电子性能和器件制造复杂化（例如，难以将湿层粘合在一起）。此外，在制造通过精确的化学功能有效隐形我们的免疫系统的材料方面也取得了进展，延迟和避免了设备故障。这些材料是无污染的或有效地模拟自然环境，避免了导致纤维化囊形成和装置故障的免疫事件级联。然而，单独的化学策略不足以长期植入器械。目前，利用机械和化学方法的集成材料平台并不存在，并构成延长植入时间的潜在解决方案。本文所述的工作是化学家和物理学家之间的合作努力，以合成不结垢的超软材料，并随后表征其机械性能，以设计用于可植入装置的下一代涂层。