On-demand continuous flow manufacturing of cannabidiol (CBD) and other cannabinoids

大麻二酚 (CBD) 和其他大麻素的按需连续流制造

• 批准号: 570513-2021
• 负责人: Charette, AndréAB
• 金额: $ 18.07万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748585
• 关键词: demand; continuous; flow; manufacturing; cannabidiol

The partnership between BioVectra Inc. and Prof. André B. Charette-Université de Montréal is a milestone towards an in-house Canadian manufacturing of high quality compounds in order to meet an increasing Canadian market demand. This approach will allow to mitigate Canada's heavy reliance on foreign suppliers and hence empower the Canadian economy and health care system. Specifically, the goal of this partnership is to develop an efficient synthetic route under continuous flow conditions to manufacture and supply on demand the two advanced intermediates, olivetol and p-menthadienol in order to make highly pure cannabidiol (CBD). These two precursors are very expensive and are currently supplied from China. A cost analysis has shown that if the costs of production of these two advanced intermediates are decreased, the cost of a 100% Canadian-made CBD would be favorably compete with its current price. The optimal synthetic procedure using continuous flow techniques will be develop within the Center for Continuous Flow Synthesis (CCFS), a state of the art laboratory located at Université de Montréal. The optimized process will then be effectively transfer to BioVectra's continuous flow large scale manufacturing facility for mass production and market distribution of CBD. This partnership is a turn-key solution to rapidly, safely and effectively supply the North American market with this important API. Through this partnership, trainees will gain experience in solving real world problems and well thought after pluri-disciplinary knowledge that will promote their successful entrance in the work force.

BioVectra Inc.安德烈教授B。蒙特利尔夏雷特大学是加拿大内部制造高品质化合物的一个里程碑，以满足不断增长的加拿大市场需求。这种做法将有助于减轻加拿大对外国供应商的严重依赖，从而增强加拿大经济和医疗保健系统的能力。具体而言，该合作伙伴关系的目标是在连续流动条件下开发一种有效的合成路线，以按需生产和供应两种高级中间体橄榄酚和对薄荷二烯醇，以生产高纯大麻二酚（CBD）。这两种前体非常昂贵，目前由中国供应。成本分析表明，如果这两种高级中间体的生产成本降低，100%由葡聚糖制成的CBD的成本将有利地与其当前价格竞争。使用连续流技术的最佳合成程序将在连续流合成中心（CCFS）内开发，该中心是位于蒙特利尔大学的最先进实验室。优化后的工艺将有效地转移到BioVectra的连续流大规模生产设施，用于CBD的大规模生产和市场分销。这种合作关系是一种交钥匙解决方案，可以快速、安全、有效地向北美市场供应这种重要的API。通过这种伙伴关系，受训者将获得解决真实的世界问题的经验，并在多学科知识之后获得良好的思考，这将促进他们成功进入劳动力市场。