Environmental Fate of Emerging Contaminants

新兴污染物的环境归宿

• 批准号: RGPIN-2022-04183
• 负责人: Sauvé, Sébastien
• 金额: $ 2.62万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748707
• 关键词: Environmental; Fate; Emerging; Contaminants

My research seeks to provide the most relevant information on which emerging contaminants have the potential to cause impact and deleterious effects for human health and the environment. I focus on contaminants and problems for which my earlier work and the scientific literature shows the most potential for risks. I am always careful not to simply measure concentrations of contaminants but integrate more mechanistic studies of their behavior and environmental fate issues (transformation, bioavailability and transport), their impacts on biological systems and the means through which we can remediate or prevent the pollution. Because of the significant challenge in measuring the ultratrace levels of many of those contaminants, development of new methods and proper validation of such analytical chemistry methods are critical before their application to real world matrices. My focus will be on non-target analysis of emerging contaminants and their metabolites and by-products. I intend to expand and pursue the work on the analysis of an expanded range of cyanotoxins, expand the work on the analysis of PFOS. Evaluate the relative contribution of water and food to the exposure to cyanotoxins and PFOS; integrating the importance of metabolites, degradation by-products and the role of particulate-bound contaminants in drinking water and weighing the relative impacts and exposure coming from food vs. water. I have also just recently acquired a GC-HRMS Orbitrap system and will develop new methods for the less measured lipophilic PFOS, cyanotoxins and also integrate the use of the pyrolysis system for the analysis of plastic polymers in water, sediments, soil amendments and biological tissues. Analytical objectives: I plan to use HRAM-MS to further enhance our analytical capacity to do non-target analysis and develop methods to retrospectively question archived full-scan HRAM-MS to provide semi-quantitative estimates of concentrations. I seek to devellop procedures on how to best do the initial analysis for optimal data archiving value. I will also apply my expertise with LC-HRAM-MS to integrate analytical developments with HRAM-MS GC-Orbitrap methods.  We will also be able to use non-target GC analysis to seek out by-products of PFAS, pesticides and pharmaceutical residues that are difficult to analyse using LC. I also want to combine the GC-Orbitrap system with a pyrolysis interface to develop an expertise in my lab to target plastic polymers including degradation by-products. Environmental objectives:  I will focus on three issues; 1) bioaccumulation of PFOS into organisms; 2) bioaccumulation, transformation and transfer of cyanotoxins; 3) quantify trace levels of plastic polymers and their degradation by-products that occur in water. and other matrices

我的研究试图提供关于哪些新出现的污染物可能对人类健康和环境造成影响和有害影响的最相关信息。我把重点放在污染物和问题上，我的早期工作和科学文献显示，这些污染物和问题最有可能带来风险。我总是小心翼翼地不简单地测量污染物的浓度，而是整合对它们的行为和环境命运问题(转化、生物可用性和运输)、它们对生物系统的影响以及我们可以补救或防止污染的手段的更多机械性研究。由于在测量其中许多污染物的超痕量水平方面存在重大挑战，在将这些分析化学方法应用于现实世界的基质之前，开发新方法并对其进行适当的验证是至关重要的。我的重点将是对新出现的污染物及其代谢物和副产品进行非目标分析。我打算扩大和继续更广泛的氰基毒素分析工作，扩大全氟辛烷磺酸的分析工作。评估水和食物对氰基毒素和全氟辛烷磺酸暴露的相对贡献；综合代谢物、降解副产品和饮用水中颗粒结合污染物的作用的重要性，并权衡食物和水的相对影响和暴露。我最近还收购了GC-HRMS Orbitrap系统，并将开发新的方法来分析较少测量的亲脂性全氟辛烷磺酸、氰基毒素，并将热解系统用于水、沉积物、土壤改良剂和生物组织中塑料聚合物的分析。分析目标：我计划使用HRAM-MS进一步增强我们进行非靶标分析的分析能力，并开发方法回溯询问存档的全扫描HRAM-MS，以提供浓度的半定量估计。我试图制定关于如何最好地进行初步分析以获得最佳数据存档价值的程序。我还将应用我在LC-HRAM-MS方面的专业知识，将分析开发与HRAM-MS GC-Orbitrap方法相结合。我们还将能够使用非靶标GC分析来寻找难以使用LC分析的全氟辛烷磺酸、杀虫剂和药物残留的副产品。我还想将GC-Orbitrap系统与热解界面结合起来，在我的实验室开发针对塑料聚合物的专业知识，包括降解副产品。环境目标：我将重点关注三个问题：1)全氟辛烷磺酸在生物体中的生物积累；2)氰基毒素的生物积累、转化和转移；3)量化水中塑料聚合物及其降解副产物的痕量水平。和其他矩阵