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Identifying key E3 ubiquitin ligases that target disease-associated mutant cytosolic proteins for degradation

Identifying key E3 ubiquitin ligases that target disease-associated mutant cytosolic proteins for degradation
鉴定针对疾病相关突变胞质蛋白进行降解的关键 E3 泛素连接酶
批准号：
476168
负责人：
Baker Heather A
金额：
$7.65万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-11-01 至 2025-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=476168&lang=en
关键词：
Chaperones Missense Mutations Protein Degradation Protein Misfolding Protein Quality Control Rare Genetic Diseases Ubiquitin Ubiquitin Ligases Ubiquitin-Proteasome System

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Proteins are vital biological machines that ensure the survival of a cell. They participate in almost all crucial cellular functions, such as energy production, damage detection, and the facilitation of critical biological responses. The DNA that codes fo
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