Modeling the Mechanical Behavior of the Periodontal Ligament in Response to Externally Applied Loading

模拟牙周膜响应外部载荷的机械行为

• 批准号: RGPIN-2017-05606
• 负责人: Romanyk, Dan
• 金额: $ 3.35万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=750695
• 关键词: Modeling; Mechanical; Behavior; Periodontal; Ligament

In 2012, the Canadian Institute for Health Information estimated that over $11 billion dollars was spent by Canadians on dental care, with this number projected to rise. One primary area of importance to dentistry is the periodontal ligament (PDL), connective tissue joining the tooth to the surrounding alveolar bone. The PDL plays a critical role in tooth support, distributing applied loads, and facilitating tooth movement during orthodontic treatment. As a result, having a complete understanding of PDL response to applied loading is vital to the field of dentistry. The objective of this program is to investigate the viscoelastic behavior of the PDL and further our understanding of how it effects load distribution in the tooth-PDL-bone complex (TPBC).A combination of experimental and mechanical modeling approaches will be utilized in the study of PDL mechanics. Creep-strain and stress-relaxation experiments will be conducted for isolated PDL tissue, and this experimental data will be used to develop and validate nonlinear viscoelastic mechanical models in both loading modalities. Interrelation methods will also be used to explore relating model coefficients in creep-strain to those in stress-relaxation, and vice versa. Finite element analysis (FEA) methods will be employed to study the mechanics of the complete TPBC. Viscoelastic models developed in our research will be incorporated into the predictive FEA model for PDL tissue. In addition, fibre optic strain measurement techniques will be used to gather ex vivo data from the PDL in complete TPBC experiments towards FEA model development and validation; something that has yet to be achieved in the literature. One PhD, two MSc, and at least one undergraduate student per year will be trained throughout this program.The proposed projects include modeling and experimental streams, and form a well-rounded methodology to investigate PDL response to applied loading. This research has direct implications towards understanding load transfer between a tooth and surrounding bone through the PDL. Such information is vital to general dentists, restorative dentists (e.g. implant mechanics), and orthodontists. In the long-term, this research will lead to improved implant and orthodontic appliance design and development for dental care recipients. Furthermore, the methods used in this program will have applications in other areas of research where nonlinear viscoelastic materials are of interest. Such materials would include polymer composites or other biological tissues (e.g. tendons or ligaments).

2012年，加拿大健康信息研究所估计，加拿大人在牙科护理上花费了超过110亿美元，预计这一数字将上升。 牙周膜（PDL）是连接牙齿和周围牙槽骨的结缔组织。PDL在正畸治疗期间在牙齿支撑、分配施加载荷和促进牙齿移动方面发挥着关键作用。因此，全面了解PDL对施加载荷的反应对牙科领域至关重要。本课题的主要目的是研究牙周膜的粘弹性行为，并进一步了解牙周膜对牙-牙周膜-骨复合体（TPBC）中载荷分布的影响，采用实验和力学模拟相结合的方法对牙周膜进行力学研究。蠕变应变和应力松弛实验将进行隔离PDL组织，该实验数据将用于开发和验证非线性粘弹性力学模型在两种加载模式。还将使用相关方法来探索蠕变-应变模型系数与应力松弛模型系数之间的关系，反之亦然。有限元分析（FEA）方法将被用来研究完整的TPBC的力学。在我们的研究中开发的粘弹性模型将被纳入预测的有限元分析模型的PDL组织。此外，光纤应变测量技术将用于在完整的TPBC实验中收集PDL的离体数据，以进行FEA模型开发和验证;这在文献中尚未实现。一个博士，两个硕士，每年至少有一个本科生将在整个程序中进行培训。拟议的项目包括建模和实验流，并形成一个全面的方法来研究PDL对应用负载的响应。这项研究对理解牙齿和周围骨之间通过PDL的负荷转移有直接的影响。这些信息对于普通牙医、修复牙医（例如种植体力学）和牙科医生至关重要。从长远来看，这项研究将导致改善种植体和正畸矫正器的设计和发展的牙科护理接受者。此外，该计划中使用的方法将应用于非线性粘弹材料感兴趣的其他研究领域。这种材料将包括聚合物复合材料或其他生物组织（例如肌腱或韧带）。