Improving immune response to vaccines by selective targeting of epithelial regions with the Nanopatch.

通过使用 Nanopatch 选择性靶向上皮区域来改善对疫苗的免疫反应。

• 批准号: DP1093281
• 负责人: Prof Mark Kendall
• 金额: $ 57.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-05-15 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093281
• 关键词: Improving; immune; response; vaccines; selective

Vaccination protects us from infections like measles and flu. In principle, it could protect us from all diseases, even from skin cancer and arthritis. In practice, however, vaccines to diseases like cancer have largely proved ineffective. One problem is that we don't really understand how the body's immune system responds to vaccination. Our aim, therefore, is to investigate changes in the immune system when a vaccine enters the skin, as might happen by injection. Experimenting with laboratory mice and a special vaccine-injecting Nanopatch that is attached to each mouse's ear, we are starting to understand how a vaccine affects the immune cells in the skin. In the future we plan to apply this knowledge to improve vaccination in people.

接种疫苗可以保护我们免受麻疹和流感等感染。原则上，它可以保护我们免受所有疾病的侵袭，甚至皮肤癌和关节炎。然而，在实践中，针对癌症等疾病的疫苗基本上被证明是无效的。一个问题是，我们并不真正了解身体的免疫系统对疫苗接种的反应。因此，我们的目标是研究疫苗进入皮肤时免疫系统的变化，就像注射可能发生的情况。通过对实验室小鼠和贴在每只小鼠耳朵上的一种特殊的疫苗注射纳米贴片进行实验，我们开始了解疫苗如何影响皮肤中的免疫细胞。在未来，我们计划应用这一知识来改善人们的疫苗接种。