Microalgal production of high value antioxidants in Canada

加拿大微藻生产高价值抗氧化剂

• 批准号: RGPIN-2022-03932
• 负责人: Laamanen, Corey
• 金额: $ 2.11万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=753209
• 关键词: Microalgal; production; value; antioxidants; Canada

Green microalgae have been identified as a potential avenue to produce high-value antioxidants. However, a lack of optimized, cost-efficient, and non-contaminating strategies for cultivation and harvesting of microalgal biomass represents a significant barrier for realizing this potential. Developing the scientific fundamentals to allow this potential to be met is a cornerstone of my long-term goal, the development of a microalgal bioeconomy in Canada. Overcoming cultivation and harvesting challenges is the basis for the short-term goals of this proposal. As such, I have identified three short-term objectives to work towards the optimization of antioxidant production systems, namely: 1) screening and identification of bioprospected microalgae, to identify potential strains and the chronic stressors that result in antioxidant production; 2) developing cultivation and acute oxidative stress models, to provide a deeper understanding of the fundamentals of production; and, 3) determining the effect of cultivation conditions on harvesting, through a novel study of both systems combined, to provide a currently lacking scientific basis to harvesting models. Over the five years of this grant, these three objectives will allow us to develop a scientific understanding of factors affecting microalgal production systems and take a major step towards sustainable production of antioxidants from microalgae in Canada.

绿色微藻已被确定为生产高价值抗氧化剂的潜在途径。然而，缺乏培养和收获微藻生物量的优化、成本效益和无污染的战略是实现这一潜力的重大障碍。发展科学基础以实现这一潜力是我长期目标--在加拿大发展微藻生物经济--的基石。克服耕作和收获挑战是这项提案短期目标的基础。因此，我已经确定了致力于优化抗氧化剂生产系统的三个短期目标，即：1)筛选和鉴定具有生物前景的微藻，以确定导致抗氧化剂生产的潜在菌株和长期应激源；2)开发培养和急性氧化应激模型，以更深入地了解生产的基本原理；以及3)通过对这两个系统的新颖研究，确定培养条件对收获的影响，为收获模型提供目前缺乏的科学基础。在这笔赠款的五年中，这三个目标将使我们能够对影响微藻生产系统的因素有一个科学的了解，并向在加拿大利用微藻可持续生产抗氧化剂迈出重要一步。