New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level

用于理解神经元水平认知障碍的分数扩散新数学

• 批准号: DP1094680
• 负责人: Em/Prof Bruce Henry
• 金额: $ 18.81万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094680
• 关键词: New; mathematics; fractional; diffusion; understanding

As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine properties, for preventative health care. The project will maintain international collaborations, between applied mathematicians at UNSW, Sydney and biomathematicians and neuroscientists at Mount Sinai School of Medicine, New York, providing ongoing training opportunities for Australian scientists in this cutting edge biomathematical research.

随着澳大利亚人口的老龄化，由于大脑皮层老化和神经退行性变导致的认知障碍正成为该国最大的健康问题。 该项目将提供新的、更现实的数学模型，用于在神经元水平上对认知障碍的机械理解。这种理解是靶向药物的重要第一步，例如，来影响神经棘的特性，用于预防性的健康护理。 该项目将保持国际合作，应用数学家在新南威尔士大学，悉尼和生物数学家和神经科学家在西奈山医学院，纽约，提供持续的培训机会，为澳大利亚科学家在这一前沿生物数学研究。