Linking Head Kinematics and Multi-Modal Imaging Using a Finite Element Head Model to Assess mTBI Risk Mitigation

使用有限元头部模型将头部运动学和多模态成像联系起来以评估 mTBI 风险缓解

• 批准号: 558260-2020
• 负责人: Cronin, DuaneDS
• 金额: $ 31.66万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760334
• 关键词: Linking; Head; Kinematics; Multi; Modal

Mild traumatic brain injury (mTBI), commonly termed concussion, may result from rapid acceleration of the head, leading to symptoms including headache, dizziness, sensitivity to noise and difficulty concentrating. Such symptoms have also been associated with repeated sub-concussive exposures in contact sports athletes and more recently in Canadian Special Operations Forces Command (CANSOFCOM) operators. The symptoms have been associated with exposure to recoil forces from large calibre weapons and correlated with the number of exposures. This project seeks to establish linkages between: the measured kinematics of the head from volunteers exposed to recoil forces during regular training; the corresponding deformation of the brain tissue predicted by a head finite element model; advanced multi-modal MRI to identify functional, physiological and structural changes associated with repeated exposures; and ultimately to assess protective equipment. The results of this research will directly inform training procedures, monitoring protocols and exposure limits for CANSOFCOM operators to ensure safety and reduce any long term effects from occupational exposures to recoil forces. Importantly, this investigation will also quantify the efficacy of a new protection garment for attenuating the rapid head motion resulting from recoil forces. This research project will provide insights into the effects of repeated exposures that may inform sports and other sectors where mTBI occurs.

轻度创伤性脑损伤（mTBI），通常称为脑震荡，可能是由于头部的快速加速，导致头痛，头晕，对噪音敏感和难以集中注意力等症状。这些症状也与接触性体育运动员和最近加拿大特种作战部队司令部（CANSOFCOM）操作员的反复亚震荡暴露有关。这些症状与受到大口径武器的后坐力有关，并与受到的次数有关。 该项目旨在建立以下方面之间的联系：定期训练期间暴露于反冲力的志愿者头部的测量运动学;头部有限元模型预测的脑组织相应变形;先进的多模式MRI，以确定与重复暴露相关的功能，生理和结构变化;并最终评估保护设备。 这项研究的结果将直接为CANSOFCOM操作员的培训程序、监测协议和暴露限值提供信息，以确保安全并减少职业暴露对反冲力的任何长期影响。重要的是，这项研究还将量化一种新的保护服装的有效性，衰减快速头部运动所造成的反冲力。该研究项目将深入了解重复暴露的影响，这可能会为发生mTBI的体育和其他行业提供信息。