Assembling the building blocks in the blueprint of the embryonic head

该项目旨在分析和推测基因组活性，并验证在时间和空间上支持构成胚胎头部构建块的不同类型组织生成的细胞和分子机制。这些知识的获得丰富了我们对胚胎发生过程中头部形成的早期步骤的理解，这些步骤与祖状态的获得、谱系倾向的增强和早期谱系分化相关的生态位条件有关。本研究对模式生物发育生物学的预期结果为建立可能在多个哺乳动物物种中保守的发育蓝图的机制提供了框架。

This project aims to profile and impute the genome activity and validate the cellular and molecular mechanism underpinning the generation, in time and space, of diverse types of tissues that constitute the building blocks of the embryonic head. The knowledge gain enriches our understanding of the early steps of head formation during embryogenesis in the context of the niche conditions associated with the acquisition of progenitor state, enhancement of lineage propensity, and driving early lineage differentiation. Expected outcome of this research on the developmental biology of a model organism provides a framework of the mechanism of establishing a blueprint of development that may be conserved across multiple mammalian species.