Underlying neurophysiological mechanisms of non-arthritic chronic painful conditions in cats

猫非关节炎慢性疼痛的潜在神经生理机制

• 批准号: RGPIN-2019-03997
• 负责人: MortensenSteagall, PauloVinicius
• 金额: $ 2.04万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760638
• 关键词: Underlying; neurophysiological; mechanisms; non; arthritic

Chronic pain causes disability and has a negative impact on quality of life. It affects humans and cats in a similar manner and can become a long-term debilitating disease. Examples in cats include osteoarthritis, feline gingivitis-stomatitis complex, interstitial cystitis, diabetes-induced chronic pain, long-term pain after surgery due to nerve damage and trauma, among others. Unfortunately, with the exception of research on osteoarthritis, little is known about underlying pain mechanisms of other/most causes of chronic pain in cats. For example, these animals may present persistent post-surgical pain after onychectomy ("declawing"), the amputation of the third phalanx of each digit that is commonly performed in Canada and United States. Signs of pain include chronic lameness, back pain, inappropriate elimination habits, reluctance to ambulate, licking and chewing at the digits, aversion to the feet being touched, and long-term changes on weight bearing, among others. These signs lead to suffering, disability and reduced quality of life, and are a major burden to these cats as most of chronic conditions. Additionally, information on treatment for these conditions is almost inexistent. Appropriate treatment of chronic painful conditions is only possible once underlying mechanisms of pain are known. A long-term research program is urgently required to investigate these mechanisms of non-osteoarthritic chronic pain and its burden in cats, and it is the objective of this proposal. These mechanisms will be discovered using non-invasive, novel, objective measurements of pain thresholds in cats with naturally-occurring chronic painful disease. The burden of pain will be studied by using a clinical instrument (questionnaire-based assessment by veterinarian) that measure mobility, posture, among others, objective measurements and infrared imaging science (thermographic cameras that detect radiation produced by inflammation) before and after treatment with different analgesic modalities. This program will be conducted by a leading research group in feline pain management within a stimulating environment for research training and should yield optimal therapeutic interventions. It will produce an immediate impact to animal welfare.

慢性疼痛会导致残疾，并对生活质量产生负面影响。它以类似的方式影响人类和猫，并可能成为一种长期的衰弱性疾病。猫中的实例包括骨关节炎、猫牙龈炎-口腔炎复合体、间质性膀胱炎、糖尿病诱导的慢性疼痛、手术后由于神经损伤和创伤引起的长期疼痛等。不幸的是，除了对骨关节炎的研究外，对猫慢性疼痛的其他/大多数原因的潜在疼痛机制知之甚少。例如，这些动物可能在甲切除术（“翼状切除术”）（通常在加拿大和美国进行的每个手指的第三节趾骨的截肢）后出现持续的术后疼痛。疼痛的症状包括慢性跛行、背痛、不适当的排泄习惯、不愿走动、舔和咀嚼手指、讨厌触摸脚以及长期负重变化等。这些迹象导致痛苦，残疾和生活质量下降，是这些猫的主要负担，因为大多数慢性疾病。此外，关于这些疾病的治疗信息几乎不存在。只有在了解了疼痛的潜在机制后，才有可能对慢性疼痛进行适当的治疗。一个长期的研究计划是迫切需要调查这些机制的非骨关节炎性慢性疼痛及其负担的猫，这是本提案的目的。这些机制将通过对患有自然发生的慢性疼痛疾病的猫的疼痛阈值进行非侵入性、新颖、客观的测量来发现。在使用不同镇痛方式治疗前后，将使用测量活动性、姿势等的临床仪器（兽医进行的基于体温的评估）、客观测量和红外成像科学（检测炎症产生的辐射的热成像相机）研究疼痛负担。该计划将由一个领先的研究小组在猫疼痛管理中进行，在一个刺激的环境中进行研究培训，并应产生最佳的治疗干预措施。这将对动物福利产生直接影响。