Underlying neurophysiological mechanisms of non-arthritic chronic painful conditions in cats

猫非关节炎慢性疼痛的潜在神经生理机制

• 批准号: RGPIN-2018-03831
• 负责人: Steagall, Paulo
• 金额: $ 2.11万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665861
• 关键词: Underlying; neurophysiological; mechanisms; non; arthritic

Chronic pain decreases mobility and has a negative impact on quality of life. It affects humans and cats in a similar manner and can become a long-term debilitating disease. In cats, main examples include osteoarthritis, feline gingivitis-stomatitis complex, interstitial cystitis, diabetes-induced chronic pain and long-term pain after surgery due to nerve damage and trauma. Unfortunately, with the exception of research on osteoarthritis, little is known about underlying pain mechanisms of chronic pain in cats. For example, these animals can present persistent post-surgical pain after onychectomy (“declawing”), the amputation of the third phalanx of each digit that is commonly performed in Canada and United States. Signs of pain include chronic lameness, back pain, inappropriate elimination habits, reluctance to ambulate, licking and chewing at the digits, aversion to the feet being touched, long-term changes on weight-bearing, among others. These signs lead to suffering, disability and reduced quality of life, and are a major burden to these cats as most of the chronic conditions. Additionally, information on treatment is almost inexistent in most feline chronic painful conditions. A long-term research program to investigate the underlying mechanisms of non-arthritic chronic pain and its burden in cats is urgently required to address this need, and is the objective of this proposal. These mechanisms will be studied using non-invasive, novel, objective assessment of pain thresholds in cats with naturally-occurring chronic painful disease, by measuring inflammatory biomarkers and response to administration of different classes of analgesics. The burden of pain will be studied by using a clinical instrument (questionnaire-based assessment by veterinarian) that assess mobility, posture, etc., objective measurements of limb use, activity monitoring and infrared imaging science (thermographic cameras that detect radiation produced by inflammation) before and after analgesic treatment. Appropriate treatment of chronic painful conditions will be only possible once these mechanisms are known. This program will be conducted by a leading research group in feline pain management within a stimulating environment for research training and should yield optimal therapeutic interventions. It will produce an immediate impact to animal welfare and improve pain management in cats.

慢性疼痛会降低活动性，并对生活质量产生负面影响。它以类似的方式影响人类和猫，并可能成为一种长期的衰弱性疾病。在猫中，主要的例子包括骨关节炎、猫牙龈炎-口腔炎复合体、间质性膀胱炎、糖尿病引起的慢性疼痛和手术后由于神经损伤和创伤引起的长期疼痛。不幸的是，除了对骨关节炎的研究外，对猫慢性疼痛的潜在疼痛机制知之甚少。例如，这些动物在甲切除术（“翼状切除术”）后可能出现持续的术后疼痛，在加拿大和美国通常进行的每个手指的第三节趾骨的截肢。疼痛的症状包括慢性跛行、背痛、不适当的排泄习惯、不愿走动、舔和咀嚼手指、讨厌触摸脚、长期改变负重等。这些迹象导致痛苦，残疾和生活质量下降，是这些猫的主要负担，因为大多数慢性疾病。此外，大多数猫科动物慢性疼痛疾病的治疗信息几乎不存在。迫切需要一个长期的研究计划来研究猫的非关节炎性慢性疼痛及其负担的潜在机制，以满足这一需求，这也是本提案的目标。将通过测量炎症生物标志物和对不同类别镇痛剂给药的反应，对患有自然发生的慢性疼痛疾病的猫的疼痛阈值进行无创、新颖、客观的评估，研究这些机制。将通过使用评估活动性、姿势等的临床工具（兽医进行的基于尿道的评估）研究疼痛负担，镇痛治疗前后的肢体使用、活动监测和红外成像科学（检测炎症产生的辐射的热成像相机）的客观测量。只有了解了这些机制，才有可能适当治疗慢性疼痛。该计划将由一个领先的研究小组在猫疼痛管理中进行，在一个刺激的环境中进行研究培训，并应产生最佳的治疗干预措施。它将对动物福利产生直接影响，并改善猫的疼痛管理。