X-ray Detectors for the Next-generation of Medical Imaging of Breast Cancer

用于下一代乳腺癌医学成像的 X 射线探测器

• 批准号: 574408-2022
• 负责人: Tanguay, JesseJEA
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762379
• 关键词: ray; Detectors; Next; generation; Medical

X-ray mammography has contributed to a 39% reduction in breast cancer mortality in the U.S. since 1990. However, 50% of women screened annually for ten years experience a false positive, some of which lead to biopsies, causing patient anxiety and increasing health-care costs. State-of-the-art x-ray mammography units use large-area flat-panel x-ray detectors. During an image acquisition, each element of a flat-panel x-ray detector integrates all x-ray energy deposited within the element. Technological innovations are leading to photon-counting x-ray detectors, which estimate the energy of individual x-ray photons. Photon counting may enhance the classification of breast lesions (i.e. malign or benign), potentially reducing the number of unnecessary breast biopsies. Dr. Tanguay at Ryerson University is leading the development of a framework for modelling of the imaging performance of photon-counting x-ray detectors. Dr. Zhao at Stony Brook University is developing a photon-counting x-ray detector based on amorphous selenium (a-Se) technology. The Stony Brook Group's novel approach has the potential to enable large-area photon-counting breast imaging. Establishing evidence of the superiority of the Stony Brook Group's approach relative to conventional approaches is critical. Ideally, such comparisons could be made at the concept and design phase of development using realistic models of system performance. In this grant, Drs. Tanguay and Zhao combine their unique expertise to develop new tools for comprehensive, accurate modelling of a-Se photon-counting x-ray detectors. The methodologies developed in this collaboration will enable the scientific community to make evidence-based investments in the photon counting x-ray detectors that have the best potential to improve the accuracy of breast cancer screening programs in Canada and worldwide.

自1990年以来，x射线乳房x光检查使美国乳腺癌死亡率降低了39%。然而，十年来每年接受筛查的妇女中有50%出现假阳性，其中一些导致活组织检查，导致患者焦虑并增加医疗保健费用。最先进的x射线乳房x线照相术使用大面积平板x射线探测器。在图像采集过程中，平板x射线探测器的每个元件都集成了沉积在元件内的所有x射线能量。技术革新导致了光子计数x射线探测器，它可以估计单个x射线光子的能量。光子计数可以增强乳腺病变的分类（即恶性或良性），潜在地减少不必要的乳腺活检次数。瑞尔森大学的Tanguay博士正在领导开发一种框架，用于模拟光子计数x射线探测器的成像性能。石溪大学的赵博士正在开发一种基于非晶硒（a- se）技术的光子计数x射线探测器。石溪小组的新方法有可能实现大面积光子计数乳房成像。建立证据证明石溪集团的方法相对于传统方法的优越性是至关重要的。理想情况下，这种比较可以在开发的概念和设计阶段使用系统性能的实际模型进行。在这项资助中，dr。Tanguay和Zhao结合他们独特的专业知识开发了新的工具，用于全面，准确地模拟a-Se光子计数x射线探测器。在这次合作中开发的方法将使科学界能够在光子计数x射线探测器上进行基于证据的投资，这些探测器最有可能提高加拿大和全世界乳腺癌筛查项目的准确性。