Defining the mechanisms underlying the sex bias of neurodevelopmental disorders in preclinical models of autism spectrum disorder (ASD)

定义自闭症谱系障碍 (ASD) 临床前模型中神经发育障碍性别偏见的机制

• 批准号: 477874
• 负责人: Swift-Gallant Ashlyn
• 金额: $ 67.99万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477874&lang=en
• 关键词: Autism Spectrum Disorder; Gestational Infection; Maternal Immune Activation; Neurodevelopment; Neuroimmune System; Sex Differences; Sexual Differentiation; Valproic Acid

Males are 4X more likely than females to develop autism spectrum disorder (ASD), suggesting that the biology of sex development (i.e., sex chromosomes and hormones) contributes to ASD risk. Our lab has demonstrated a male bias in ASD risk in a preclinical

男性患自闭症谱系障碍(ASD)的可能性是女性的4倍，这表明性发育的生物学(即性染色体和激素)导致了ASD的风险。我们的实验室已经证明男性在ASD风险方面存在偏见，在临床前