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Defining the mechanisms underlying the sex bias of neurodevelopmental disorders in preclinical models of autism spectrum disorder (ASD)

Defining the mechanisms underlying the sex bias of neurodevelopmental disorders in preclinical models of autism spectrum disorder (ASD)
定义自闭症谱系障碍 (ASD) 临床前模型中神经发育障碍性别偏见的机制
批准号：
477874
负责人：
Swift-Gallant Ashlyn
金额：
$67.99万
依托单位：
Memorial University of Newfoundland
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-03-01 至 2028-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477874&lang=en
关键词：
Autism Spectrum Disorder Gestational Infection Maternal Immune Activation Neurodevelopment Neuroimmune System Sex Differences Sexual Differentiation Valproic Acid

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Males are 4X more likely than females to develop autism spectrum disorder (ASD), suggesting that the biology of sex development (i.e., sex chromosomes and hormones) contributes to ASD risk. Our lab has demonstrated a male bias in ASD risk in a preclinical
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