Modulation of neuroplasticity and behaviour through parental experience

通过父母经验调节神经可塑性和行为

基本信息

  • 批准号:
    RGPIN-2022-04824
  • 负责人:
  • 金额:
    $ 2.77万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

Experience shapes the development and continued remodelling of neural circuits known as plasticity, which in turn gives rise to behavioural and cognitive variation. The cumulative experiences of parenthood, including pregnancy and the provision of parental care, are among the most important social experiences in an animal's life history. The importance of parental experience on parental brain physiology is less well-known than its role in offspring development and survival. However, changes in the brain with parenthood can impact a range of behaviours for the rest of the animal's life, including learning and memory and the regulation of stress and anxiety. All these behaviours involve the hippocampus, a highly plastic brain region that is altered through parental experience and by physiological status, such as hormonal changes that accompany the transition to parenthood. My past research in rats, a monoparental mammal in which the mother solely cares for the offspring, demonstrated that maternal experience remodels the hippocampus in the short-term and with aging. By necessity, the rarer studies on paternal experience have been performed on biparental species, but while studying fatherhood these studies typically neglect motherhood. Nonetheless, parental experience includes not only the interactions between each parent and their offspring, but between the care partners as well. We currently have a weak understanding of the extent of hippocampal remodelling with parental experience in females and males of the same species and its impact on behaviour. My proposed research program seeks to address this fundamental gap in our knowledge through a unified approach in degus, a biparental and long-lived rodent. I will first examine hippocampal remodelling and behaviour with parental experience and aging and the underlying hormonal mechanisms. I will then manipulate brain remodelling and hormonal pathways to directly link changes in plasticity with behaviour. Parenthood is a crucial experience in many animals, yet surprisingly little is known about the impact of this unique experience on the brain and with aging. The knowledge gained from this research will help us understand why parenthood remodels the brain in females and males in the short-term and with aging and its implications for behaviour. Trainees in this research program will be part of a dynamic and inclusive research environment and be encouraged to present at conferences and publish their results in scientific journals. Students will leave the lab with a range of skills in animal behaviour, neuroscience, physiology, and cellular and molecular biology, which are highly sought after in academia and transferable to the Canadian biomedical and health industries and to government laboratories.
经验塑造了被称为可塑性的神经回路的发展和持续重塑,这反过来又引起了行为和认知的变化。父母身份的累积经验,包括怀孕和提供父母照顾,是动物生活史上最重要的社会经验之一。父母经验对父母大脑生理的重要性不如其在后代发育和生存中的作用那么为人所知。然而,父母的大脑变化可能会影响动物余生的一系列行为,包括学习和记忆以及压力和焦虑的调节。所有这些行为都与海马体有关,海马体是一个高度可塑的大脑区域,它会因父母的经历和生理状态而改变,比如随着父母身份的转变而发生的荷尔蒙变化。我过去对老鼠的研究表明,母亲的经历会在短期内重塑海马体,并随着年龄的增长而改变。老鼠是一种单亲哺乳动物,母亲只照顾后代。出于必要,对双亲物种的父亲经验的研究比较罕见,但在研究父亲身份时,这些研究通常忽略了母亲身份。尽管如此,父母的经验不仅包括每个父母和他们的后代之间的互动,但照顾伙伴之间的互动。目前,我们对同一物种的雌性和雄性的海马重塑与父母经验的程度及其对行为的影响的了解还很薄弱。我提出的研究计划旨在通过一种统一的方法来解决我们知识中的这一根本性差距,这是一种双亲长寿的啮齿动物。我将首先研究海马重塑和行为与父母的经验和老化和潜在的激素机制。然后,我将操纵大脑重塑和激素途径,将可塑性的变化与行为直接联系起来。为人父母对许多动物来说是一种至关重要的经历,但令人惊讶的是,人们对这种独特的经历对大脑和衰老的影响知之甚少。从这项研究中获得的知识将帮助我们理解为什么父母身份会在短期内重塑女性和男性的大脑,并随着年龄的增长及其对行为的影响。该研究计划的学员将成为一个充满活力和包容性的研究环境的一部分,并鼓励他们参加会议并在科学期刊上发表成果。学生将离开实验室,掌握动物行为学、神经科学、生理学、细胞和分子生物学方面的一系列技能,这些技能在学术界备受追捧,并可转移到加拿大生物医学和卫生行业以及政府实验室。

项目成果

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DuarteGuterman, Paula其他文献

DuarteGuterman, Paula的其他文献

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{{ truncateString('DuarteGuterman, Paula', 18)}}的其他基金

Modulation of neuroplasticity and behaviour through parental experience
通过父母经验调节神经可塑性和行为
  • 批准号:
    DGECR-2022-00308
  • 财政年份:
    2022
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Discovery Launch Supplement
Behavioural Neuroscience
行为神经科学
  • 批准号:
    CRC-2020-00099
  • 财政年份:
    2022
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Canada Research Chairs
Behavioural Neuroscience
行为神经科学
  • 批准号:
    CRC-2020-00099
  • 财政年份:
    2021
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Canada Research Chairs
Neuroendocrine mechanisms of paternal care in mice: the role of estrogen
小鼠父亲照顾的神经内分泌机制:雌激素的作用
  • 批准号:
    403987-2011
  • 财政年份:
    2013
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Postdoctoral Fellowships
Neuroendocrine mechanisms of paternal care in mice: the role of estrogen
小鼠父亲照顾的神经内分泌机制:雌激素的作用
  • 批准号:
    403987-2011
  • 财政年份:
    2012
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Postdoctoral Fellowships
Neuroendocrine mechanisms of paternal care in mice: the role of estrogen
小鼠父亲照顾的神经内分泌机制:雌激素的作用
  • 批准号:
    403987-2011
  • 财政年份:
    2011
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Postdoctoral Fellowships
Cross-regulation between estrogen and thyroid hormone during amphibian development and the implications for endocrine disruption.
两栖动物发育过程中雌激素和甲状腺激素之间的交叉调节及其对内分泌干扰的影响。
  • 批准号:
    362674-2008
  • 财政年份:
    2010
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Postgraduate Scholarships - Doctoral

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Modulation of neuroplasticity and behaviour through parental experience
通过父母经验调节神经可塑性和行为
  • 批准号:
    DGECR-2022-00308
  • 财政年份:
    2022
  • 资助金额:
    $ 2.77万
  • 项目类别:
    Discovery Launch Supplement
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The Influence of Parental Experience On Brain Development, Behaviour, and Neuroplasticity
父母经历对大脑发育、行为和神经可塑性的影响
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    RGPIN-2016-05266
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    Discovery Grants Program - Individual
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父母经历对大脑发育、行为和神经可塑性的影响
  • 批准号:
    RGPIN-2016-05266
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    RGPIN-2018-04060
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    $ 2.77万
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    Discovery Grants Program - Individual
The Influence of Parental Experience On Brain Development, Behaviour, and Neuroplasticity
父母经历对大脑发育、行为和神经可塑性的影响
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