Developing a multimodal imaging pipeline for antisense technology

开发反义技术的多模态成像流程

• 批准号: IE230100042
• 负责人: Dr Kai Chen
• 金额: $ 32.25万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Industry Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/IE230100042
• 关键词: Developing; multimodal; imaging; pipeline; antisense

Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules across cells and tissues and refined imaging methods. This project should provide more strategic delivery of antisense molecules to specific cells and tissue, which will have significant downstream economic and social benefits to the Australian community.

反义分子代表了生命科学的革命性药物发现平台，但了解它们在细胞和组织中的分布是具有挑战性的。通过整合纳米生物技术方法，该项目预计将开发和应用创新的成像工作流程，以纳米级精度跟踪细胞和组织中的反义分子。预期成果包括这些分子在细胞和组织中运输的新知识以及改进的成像方法。该项目将为特定细胞和组织提供更多的反义分子战略性递送，这将为澳大利亚社区带来重大的下游经济和社会效益。