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Uncovering Vulnerabilities of Alternative Telomere Maintenance Systems in Cancer

Uncovering Vulnerabilities of Alternative Telomere Maintenance Systems in Cancer
发现癌症中替代端粒维持系统的脆弱性
批准号:
488585
负责人:
Marchal Alexandre
金额:
$56.01万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01

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中文摘要
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英文摘要
Telomeres protect against the gradual shortening of chromosomes, a phenomenon associated with aging but which is also relevant to diseases including cancer. To proliferate, cancer cells elongate their telomeres via various pathways that constitute potenti
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Ubiquitin-Dependent Regulation of DNA Replication during Stress
  • 批准号:
    420960
  • 项目类别:
    Operating Grants
  • 资助金额:
    $55.73万
  • 财政年份:
    2020
  • 负责人:
    Marchal Alexandre
  • 依托单位:
Roles of the PRP19 complex in the Maintenance of Genome Stability
  • 批准号:
    356161
  • 项目类别:
    Operating Grants
  • 资助金额:
    $31.49万
  • 财政年份:
    2016
  • 负责人:
    Marchal Alexandre
  • 依托单位:
海外基金