Transporting proteins to and within mitochondria

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Mitochondria are found in all of our cells and are essential for life. They act like a nuclear power plant, providing the bulk of energy - but they can also kill the cell if the mitochondrial wall (membrane) is opened. Mitochondria contain about 1000 different proteins to function properly but almost all of them are made outside the compartment and must squeeze in through narrow membrane channels. This project will provide new insights into how proteins get into mitochondria and what factors help in this process. Besides providing new information about a process that is essential for life, the project will train students in molecular cellular biology techniques and will help foster strong international collaborations.