Mitochondrial biogenesis in mammalian cells

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This project aims to understand the inner workings of a molecular machine involved in mitochondrial protein biogenesis. Mitochondria are essential organelles that provide the bulk of cellular energy. Genesis of the organelle relies on the coordinated synthesis and transport of both proteins and lipids that make up the organelle. This project plans to define the architecture of the molecular machine, outline how its components function, and explore the relationship between proteins and lipids in mitochondrial genesis. These results are expected to provide knowledge about how mitochondrial creation is regulated.