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Deciphering the role of protease-activated receptor 2 in immuno-oncology

Deciphering the role of protease-activated receptor 2 in immuno-oncology
破译蛋白酶激活受体 2 在免疫肿瘤学中的作用
批准号:
488385
负责人:
Stagg John
金额:
$73.84万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01
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中文摘要
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英文摘要
We recently identified Protease-activated receptor 2 (PAR2) as a biomarker of resistance to cancer immunotherapy in patients. PAR2 and its activating proteases are upregulated in different cancers and are expressed by various cells. PAR2 is known to have
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Targeting the extracellular adenosine pathway in pancreatic and liver cancers
Immune-stimulatory antibody-drug conjugates for treatment of breast cancer
  • 批准号:
    388207
  • 项目类别:
    Operating Grants
  • 资助金额:
    $4.81万
  • 财政年份:
    2018
  • 负责人:
    Stagg John
  • 依托单位:
Targeting the CD73-adenosine pathway in cancer
Remodeling of the tumor microenvironment by CD73: a therapeutic target
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