Tissue-engineered humanized model of the gastric tumor microenvironment to mechanistically evaluate the dynamics of combined tumor-infiltrating lymphocyte and RNA nanoparticle therapy

胃肿瘤微环境的组织工程人源化模型，用于机械评估肿瘤浸润淋巴细胞和 RNA 纳米颗粒联合治疗的动力学

• 批准号: 490149
• 负责人: Kinsella Joseph
• 金额: $ 76.63万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2028-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=490149&lang=en
• 关键词: Bioprinting; Imaging Mass Cytometry; In Vitro Bioengineered Cancer Model; Nanomedicine; Pharmacometrics; Rna Therapeutics; T-Cell Therapy; Tissue Engineering; Transcriptomics; Tumour-Infiltrating Lymphocytes

When cytotoxic immune cells encounter a tumor they are excluded from entering it due to the dense protein environment that the tumor builds to evade being attacked. In this proposal, we will create personalized models of gastric cancer to study the mecha

当细胞毒性免疫细胞遇到肿瘤时，由于肿瘤为逃避攻击而构建的密集蛋白质环境，它们被排除在进入肿瘤之外。在本提案中，我们将创建 个性化的胃癌模型，以研究其机制