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Characterization of the T cell populations that regulate autoimmunity in asymptomatic anti-nuclear positive individuals and how they become altered in early untreated systemic autoimmune rheumatic disease

Characterization of the T cell populations that regulate autoimmunity in asymptomatic anti-nuclear positive individuals and how they become altered in early untreated systemic autoimmune rheumatic disease
无症状抗核阳性个体中调节自身免疫的 T 细胞群的特征及其在早期未经治疗的系统性自身免疫性风湿病中的变化
批准号：
490019
负责人：
Wither Joan E
金额：
$66.32万
依托单位：
University Health Network (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2028-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=490019&lang=en
关键词：
Anti-Nuclear Antibodies Immune Profiling Immune Regulation Interferon Single Cell Transcriptomics Sjogren'S Disease Systemic Lupus Erythematosus T Cells

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中文摘要
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英文摘要
Systemic Lupus Erythematosus and Sjogren's Disease, are Systemic Autoimmune Rheumatic Diseases (SARD) that share many clinical, immune, and genetic features, including high blood levels of antibodies that react against the nucleus of the patient's own cel
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