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Structure-Toxicity Relation of Fibrillogenic Fragments in Human Prion Protein and Implications on Neuronal Cells

Structure-Toxicity Relation of Fibrillogenic Fragments in Human Prion Protein and Implications on Neuronal Cells
人朊病毒蛋白中纤维化片段的结构-毒性关系及其对神经元细胞的影响
批准号：
201031
负责人：
Yau Jason H
金额：
$1.27万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-02-01 至 2011-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=201031&lang=en
关键词：
Amyloid Fibril Cell Toxicity Neurodegenerative Disease Protein Structure Solid State Nuclear Magnetic Resonance

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The formation of plaques in brain tissues is characteristic of many neurodegenerative disorders such as Alzheimer's and prion diseases. While the proteins associated with these diseases are different, they all involve the accumulation of misfolded aggreg
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