最新研究表明Ⅱ型固有淋巴细胞（ILC2）是参与哮喘发生发展的重要免疫细胞。IL-33、IL-25、TSLP为诱导ILC2活化的上游细胞因子，其中以IL-33最为关键。IL-33与ILC2表面的ST2受体相互作用形成的IL-33／ST2轴，在哮喘的病理过程中发挥重要作用。傈僳族药白背叶楤木民间用于治疗哮喘，但其活性成分和作用机制不清。我们前期研究发现，白背叶楤木总皂苷可显著改善哮喘小鼠的病理症状，同时降低哮喘小鼠肺泡灌洗液中ILC2活化的上游细胞因子IL-33、IL-25、TSLP的分泌,故推测白背叶楤木中皂苷类成分能靶向调节ILC2及IL-33／ST2轴而发挥治疗哮喘的作用。本项目拟进一步对白背叶楤木总皂苷进行化学成分研究，阐明其抗哮喘的物质基础，并探讨其以ILC2为核心的防治哮喘的作用机理，为哮喘的临床治疗提供一种靶向ILC2的新策略，也为从民族药用植物资源中开发抗哮喘药物提供科学依据。

In recent studies, type Ⅱ innate lymphoid cells(ILC2) is the important immune cells of asthma. IL-33, IL-25 and TSLP are the key cytokines in the activation of ILC2. IL-33/ST2 axis mediated by the interaction of IL-33 and its receptor ST2 in ILC2 is involved in the pathological process of asthma. Lisaw national medicinal plant Aralia chinensis L. var. nuda Nakai, has been used clinically for prevention and treatment of asthma, which is rich in triterpenoids. Preliminary study suggested that total saponions in Aralia chinensis L. var. nuda Nakai(TS) can significantly improve the inflammatory cell infiltration and goblet hyperplasia of asthmatic mice. In addition, it reduced the secretion of IL-33, IL-25 and TSLP in bronchoalveolar lavage fluid of asthmatic mice, which are the activation molecules of ILC2. Based on this, it is reasonable to speculate that TS may affect the pathogenesis of asthma through ILC2 and IL-33/ST2 axis. This project study the chemical composition of TS systematically，clarifying the material basis of TS for preventing asthma, clearing the anti-asthmatic effects of TS, and exploring its anti-asthmatic mechanism as the core of ILC2. Besides, this work will provide novel therapeutic strategies for asthma targeting ILC2, and provide scientific data for the development and utilization of the ethnic plant resources.