年龄相关性黄斑变性是中老年人群重要的致盲性眼病，患病率高，病因复杂。本课题拟对沿海内陆50岁以上人群（9485人）年龄相关性黄斑变性进行流行病学横断面研究调查，目的是探索年龄相关性黄斑变性不同区域间的分布特征及流行趋势，主要相关危险因素，探讨遗传与环境等因素对年龄相关性黄斑变性的影响，及疾病适宜的干预措施。主要研究内容包括：1.沿海内陆不同区域50岁以上人群年龄相关性黄斑变性的患病情况；2.年龄相关性黄斑变性人群患病的相关危险因素；3.分析人群年龄相关性黄斑变性的遗传特征，探索遗传与环境因素对年龄相关性黄斑变性的影响；4.通过研究城乡人群的特征性差异，探索眼保健水平等对年龄相关性黄斑变性的影响。本研究具有资料影像数字化，诊断标准化、智能化，遗传与环境因素相结合的特征，将是国内首个沿海内陆及城乡覆盖的流行病学横断面研究，为我国年龄相关性黄斑变性防治策略的制定提供循证学依据。

Age-related macular degeneration is an important blind-causing eye disease in the middle age and old people, and has high prevalence and complicated risk factors. This study is to investigate epidemiology of age-related macular degeneration for coastal and inland people over the age of 50 years old (9485 persons) by cross-sectional study. Aimed to explore the distribution, trend and risk factors of age-related macular degeneration between different areas, to explore the influence by genetic and environmental factors and the appropriate intervention measures for the disease. The contents of the study include: 1. the prevalence of age-related macular degeneration people over the age of 50 years old between the coastal and inland regions; 2. The related risk factors of age-related macular degeneration; 3. to analyze the genetic characteristics of age-related macular degeneration and explore the effects of genetic and environmental factors on age-related macular degeneration; 4. to explore the effect of eye health level on age-related macular degeneration by studying the characteristics of urban and rural population. This study is equipped with the characteristics of digitization of image data , standardization of diagnosis, assistance by artificial intelligence and characteristics of study combining genetic and environmental factors. The project will be the first domestic epidemiological study for age-related macular degeneration covering coastal and inland area in both urban and rural areas, and will provide evidence for the establishment of control strategy of the disease.