生物材料异物反应能够引起无菌性炎症、周围组织粘连以及纤维化等不良反应，导致组织功能退化与材料功能失效。目前，科研人员主要通过改变材料固有的理化性质降低异物反应，然而这种工艺优化的工程手段忽略了背后复杂的生物学响应过程。因此，本研究基于生物学机制为导向的材料设计理念，拟建立一种“仿生”的磷脂膜表面修饰技术，以静电纺丝纳米纤维支架作为模式材料，利用天然细胞膜对材料进行“伪装”来隐藏外来植入材料的“异物”身份。理论上旨在利用细胞膜蛋白对促炎症因子的特异性亲和能力，通过竞争性吸附来抑制局部促异物反应的相关炎症信号。申请者拟采用共价基团功能化磷脂膜，或提取天然巨噬细胞膜，或将以上两者相结合，通过自组装与点击化学等技术构建细胞膜表面功能化纳米纤维支架，探索其对巨噬细胞分型极化、材料与组织界面异物反应的影响。本项目的实施将为改善生物材料的异物反应提供新的实验技术与理论依据。

Foreign body reaction of biomaterial can cause adverse reactions such as aseptic inflammation, surrounding tissue adhesion, and fibrosis, leading to deterioration of tissue function and failure of the material function. At present, researchers mainly rely on regulating the inherent physical and chemical properties in materials to reduce foreign body reactions. However, these process optimization engineering methods ignore complex biological responses. Therefore, based on the biological guiding mechanism of material design concept, this study intends to establish a “biomimetic” surface modification technology, using electrospun nanofibrous scaffolds as a model platform, using the natural cell membrane to "guise" the material to hide the "foreign" identity of external implant materials. Theoretically, it aims to utilize the specific affinity of cell membrane proteins for pro-inflammatory factors to inhibit the associated inflammatory signals by competitive adsorption. We intend to use chemical functional groups to functionalize phospholipid membranes, or extract natural macrophage membranes, or combine the above two, and construct cell membrane surface functionalized nanofiber scaffolds by self-assembly and click chemistry techniques to explore the macrophages polarization, foreign body reaction between material and tissue interface. The implementation of this project will provide new experimental techniques and theoretical basis for reducing the foreign body reaction of biomaterials.