深脑神经成像芯片是一种能够监测神经元信号的微电极阵列芯片，可用于神经疾病精确诊断与定点治疗、实时精确脑解析。. 本项目瞄准前沿神经医学和认知科学研究的需求，开展高分辨率单片式CMOS深脑神经成像芯片的研究工作：提出一种微电极阵列原位信号处理方法，突破信号通道数量的限制，实现高分辨率、无死区的神经信号成像；提出一种片内变换压缩方法，大幅降低输出吞吐速率限制；研制单杆1024通道深脑神经成像芯片，研究压缩图像的重构、滤波降噪等算法与电路，完成神经信号成像试验。. 本项目的成果将为满足精确神经诊断、精确脑解析等神经医学和认知科学领域的迫切需求奠定理论和技术基础。

Deep brain neural signal imaging chip, which can be used for accurate point-of-care diagnostics of neural disease and real-time precise brain analysis, is a chip contains microelectrode array that can monitor neural signal. .This project aims to address the needs of frontier neuromedicine and cognitive science and research to carry out the development of high-resolution monolithic CMOS deep brain neural signal imaging chip. A microelectrode array in-situ signal processing method is proposed, which breaks through the limitation of the number of signal channels and achieves high-resolution, dead-zone-free imaging of neural signals. An on-chip transform and compression method is proposed to reduce the throughput limitation greatly. Accordingly, a single-shank, 1024-channel deep-brain neural signal imaging chip is developed. The algorithms and circuits of image reconstruction, filtering and denoising are studied, and the imaging experiment of neural signals is completed..The achievements of this project will lay the theoretical and technical foundation for meeting the urgent needs in the field of neuromedicine and cognitive science such as accurate neural diagnosis and precise brain analysis.