我国一种新发现的沙粒病毒与人类疾病关系的研究

申请人前期在云南居民区生活的优势鼠种—黄胸鼠和褐家鼠中发现存在着一类沙粒病毒的感染，完成了5株沙粒病毒的全基因组测序，比较发现这种沙粒病毒与浙江发现的温州病毒最为相似。在不明原因发热病人血清中检测到这种病毒的抗体，提示这类沙粒病毒可感染人。而我国至今除淋巴细胞性脉络丛脑膜炎病毒外，没有其它沙粒病毒感染人的病例报道。黄胸鼠和褐家鼠是云南居民区活动的优势家鼠，分布范围广，与人的关系十分密切。因此，有必要对这2种优势家鼠所携带的沙粒病毒开展系统的研究。本研究是在前期工作的基础上，进一步调查这类沙粒病毒的感染现状、遗传变异以及病毒与宿主动物的进化关系；阐明该类病毒与人类疾病的关系，为沙粒病毒的监测、预防和控制提供科学指导。

We found that there are the new genotypes of Arenavirus（ARV）in the dominant rodents (Rattus tanezumi and Rattus norvegicus) in residential areas in Yunnan Province, China and the genomes of the five strains of ARV have been sequenced. It is discovered that ARV harbored by rodents in Yunnan province is the most similar to that of Wenzhou virus reported in Wenzhou city, Zhejiang province, China. There is no any case infected with ARV except lymphocytic choriomeningitis virus in China. It was detected that the antibody against ARV among patients with unknown fever in Yunnan province. The hosts (R. tanezumi and R. norvegicus) are the dominant rodents in residence community distributed all over Yunnan province and their activities are very closely related to production and living of human. So it is necessary to perform a system research on ARV harbored by the hosts (R. tanezumi and R. norvegicus). On the basis of previous work, this study makes further investigation on the infected situation, genetic variation of ARV, and the evolutionary relationships among the ARV and hosts. The study reveals the pathogenicity of ARV to human for providing technical guidance of surveillance, control and prevention of ARV in Yunnan province.