本课题基于中药多成分协同作用，利用生物医药新材料的特殊性能, 通过固态脂质均相包封、液态脂质与固态脂质混合包封、磷脂修饰的脂质载体等三种形式，进行中药多成分新型纳米递药系统的设计、组装与评价,以分子量差异小、理化性质差异较大和油水分配系数差异大的三组代表性中药多成分为切入点,在优选载体材料、添加致孔剂等基础上，优化工艺参数，通过包合/吸附、改变储药空间和调控释药速度等手段，建立中药多成分纳米递药体系，阐明中药多成分平衡包封和均衡释药的规律。从而实现由中药单一成分向多成分新型递药系统的转变，力图创建具有中药特色的现代中药纳米递药模式，研究成果不仅可为现代给药技术应用于传统中药体系提供科学依据，而且可为构建体内外均衡释放、持久起效、靶向定位的中药多成分纳米化技术平台提供科学参考，为以有效部位为治疗药物的现代剂型设计提供借鉴。更为重要的是还可丰富中医药理论的现代化内涵，促进中医药理论不断创新。

As is known that multicomponents of TCM are useful in the treatment of human serious disease,such as tumor,cardiovascular disease and hepatitis.However,many fatal weaknesses reduce their curative effect.For example,the toxic properties of the total alkaloids of Semen Strychni limit its application,oleanolic acid has low bioavailability due to its lower solubility. It is a key issue of the low bioactivity and safety of TCM composite. Nanoparticles delivery system are one of the best drug loaded cartiers for controlling drug release and targeting treatment of carcinoma and hepatitis..This research is based on the synergistic effect of TCM composite by using new biological material to design and evaluate New nano lipid deliverydrug system,which has special properties coupling with weak electricity and offered good hydrophilic and oleophilic properties. We preparea new nanolipids carrier delivery drug system by choosing representative multicompents of TCM, in order to improve curative effect and to solve existing problems of multicomponents of TCM.. Solid lipid homogeneous encapsulation will be used for enveloping multicomponents, which has a few difference of their physicochemical properties. Nanostructured lipid carriers be used for encapsulating multicomponents which has more differences of their hydrophilic lipophilic properties. For multicomponents which has more differences of their physicochemical properties,we enloaded it by using a Novel Nanoparticles Modificated Phospholipid layer. All of them will be prepared by the reverse micelle double emulsify method. Emulsifier and stabilizer will be chosed and its amounts should be optimized ,so as to build up a safety, high efficiency novel nano lipid delivery system. We also design the targeted type and longterm nano-structured lipid delivery system, and evaluate them by the balance envelopement and equilibrium release principle. We hope that the research of single component nanoparticles turn into multicomponents．We try to create the TCM mode, with its characteristics of modern nanometer pass medicine multicomponents so as to improve the level of the treatment of cancer and liver disease. It will be supposed that our reserch can provide a theoretical foundation and design basis for other multicomponents of TCM.