艾滋病是当今最严重的流行病之一，国际上主要采用高效抗反转录病毒（HAART）疗法治疗艾滋病，但HAART疗法存在严重的不良反应，故HAART疗法常联合使用中药治疗艾滋病，已证实中药YAK能够改善HIV/AIDS患者临床症状，稳定和提高患者免疫功能，降低不良反应的发生率和程度，尤其是减少HIV/AIDS患者机会性感染发生频次，从而提高患者生存质量，降低死亡率。抗艾滋病中药YAK虽然在临床上取得了较好疗效，但目前对于YAK的抗艾作用机制未见报道，这在很大程度上制约了中药YAK的推广。本项目利用药物相互作用（DDI）理论，从整体动物、组织、细胞不同层面，采用PK-PD技术、血清药理学方法、Western Blot技术研究YAK抗艾滋病的作用机制，为中药治疗艾滋病提供更多的实验数据支撑，对临床上更好的使用中药预防、治疗艾滋病有重要的作用，同时可以建立抗艾滋病中药的筛选平台，促进抗艾滋病中药的发展。

Acquired Immune Deficiency Syndrome (AIDS) is one of the most serious epidemic diseases nowadays. Highly Active Anti-Retroviral Therapy (HAART) is most often used to treat AIDS, but it has severe adverse reactions. So HAART is frequently combined with traditional Chinese medicine to treat AIDS. It has proved that YAK ameliorated clinical symptoms of HIV/AIDS patients, stabilized and improved their immune function and reduced adverse reactions, especially opportunistic infections. YAK improves quality of life in HIV/AIDS patient and lowers mortality rate. Although YAK shows excellent therapeutic effect in treatment of AIDS, its anti-AIDS mechanism has not been reported so far, which restricts the popularization of YAK. Based on drug-drug interaction (DDI), this project will explore anti- AIDS mechanism of YAK using PK/PD approach, serum pharmacology method and Western blotting technology. The researches will be performed using animals, tissues and cells. The results could provide more laboratory data support for treatment of AIDS with traditional Chinese medicine and play an important role in clinical prevention and treatment of AIDS with traditional Chinese medicine. Besides, screening platform for anti-AIDS traditional Chinese medicine would be established and promote the development of anti-AIDS traditional Chinese medicine.