血小板凋亡在血小板数量减少疾病发生中的作用及其机制研究

可导致致命性出血的血小板数量减少时常发生在一些常见疾病中，如感染、免疫性血小板减少症（ITP）、糖尿病、肿瘤等，然而，这些疾病中发生血小板数量减少的机制尚未完全明确。血小板凋亡是体内清除衰老血小板的一种主要方式，申请人及其他学者研究表明，病理因素也能够诱导血小板发生凋亡，从而导致血小板减少。本研究将在前期工作基础上，选择感染、ITP和糖尿病病人为研究对象，探明血小板凋亡在这些疾病发生血小板数量减少中的作用；探明这些疾病中诱导血小板发生凋亡的因素及其导致凋亡的机制，并在体外和动物体内实验中研究验证；根据新发现的机制，研究探讨预防和治疗这些疾病中血小板数量减少的新方法。因而，本项目的实施，将有可能揭示不同疾病中发生血小板数量减少的共性机制，找到预防和治疗血小板减少的方法，对减少或避免不同疾病中出血、甚至死亡意外的发生具有重要理论意义和临床应用价值。

Thrombocytopenia which could incur life-threatening hemorrhage often occurs in many common diseases, such as infections, immune thrombocytopenia (ITP), diabetes, as well as malignant disease. The mechanism, however, remains unclear. Increasing evidence indicates that apoptosis delimits platelet lifespan and survival, and leads to thrombocytopenia in many common diseases. In this study, we will reveal the role of platelet apoptosis in thrombocytopenia in patients with ITP, diabetes and bacterial infections. We will identify the mechanism of apoptosis in the regulation of thrombocytopenia both in vitro and in vivo, and determine the value of inhibiting platelet apoptosis in the prevention and treatment of thrombocytopenia. Therefore, this study may disclose the mechanism of thrombocytopenia. Regulation of platelet apoptosis may have profound implications for the prevention and treatment of platelet number-related diseases.