伴随着人类社会的发展，视网膜光损伤问题日益严重。多年来，国内外学者对视网膜光损伤进行了大量的研究，但其发病机制仍不清楚。尽管对治疗光损伤进行了大量研究，但其机理未被阐明。滋阴明目丸在临床应用多年，对光损伤相关性视网膜病变有良好疗效，值得进一步研究。 视细胞凋亡是视网膜光损伤中的重要机制之一。而细胞凋亡受多种基因调控, p53及Bcl-2基因均是与细胞凋亡相关的基因。Bcl-2基因是一种重要的抑制凋亡的基因，p53基因其主要生物学功能是引起细胞周期阻滞，诱导细胞凋亡和分化。二者之间可能通过双向调节的结果抑制视细胞的凋亡。 本研究从细胞凋亡着手，探讨细胞凋亡的基因双向调节机制。从而，为视网膜光损伤的中医药治疗以及探寻新的替代治疗药物提供理论支持。

With the development of human society, the increasingly serious problem of retinal light damage. Over the years, the domestic and foreign scholars on retinal light damage done a lot of research, but its pathogenesis is still unclear. Although the treatment of photodamaged did a lot of research, but the mechanism has not been elucidated. Ziyingmingmu pill in clinical application for many years, the light injury associated retinopathy has good effect, worthy of further study. Apoptosis is one of the important mechanisms of retinal light damage. And apoptosis is controlled by many genes, p53 and Bcl-2 gene are associated with apoptosis gene. Bcl-2 gene is an important inhibition of apoptosis gene, p53 gene and its main biological function is to block cell cycle, induce cell apoptosis and differentiation. May the bidirectional regulation results in inhibition of optic cell apoptosis between the two. This study begins from the cell apoptosis, apoptosis gene of bidirectional regulation mechanism. Thus, to provide theoretical support for the Chinese medicine treatment of retinal light damage and to search for the substitution of new drugs.