细胞受控死亡方式主要包括凋亡、程序性坏死、焦亡和铁死亡等。我们在前期研究中发现，在I型酪氨酸血症引起的肝损伤过程中，肝实质细胞会采用一种不同于已知的细胞受控死亡方式的新型细胞死亡方式。在该新型细胞死亡过程中，细胞会通过促进铁积累抑制细胞死亡。在HBV感染引起的肝硬化组织中，也存在类似的铁积累现象。然而，该新型细胞死亡方式的调控和执行机制依然不清楚，其参与肝损伤和肝癌发生的机制也有待研究。本课题我们将对这一类新型细胞死亡方式进行鉴定，找到调控该细胞死亡方式的关键基因和信号通路，初步阐明其调控和执行机制，并解释其参与肝损伤和肝癌发生的原理。

Regulated forms of cell death include apoptosis, necroptosis, pyroptosis, ferroptosis, as well as other non-apoptotic cell death. In our previous studies, we found that hepatocytes underwent a new form of regulated cell death during type I tyrosinemia induced liver injury. This new form of regulated cell death is different from other known regulated cell death forms. During this new form of regulated cell death, the cells accumulate iron to inhibit cell death. Similar iron accumulation is also found in HBV related liver cirrhosis tissues. However, it is still unclear how this new form of regulated cell death is regulated and how it contributes to liver injury and liver tumorigenesis. In this study, we will characterize this new form of regulated cell death, find critical genes and signaling pathways regulating this cell death process, illuminate its regulation mechanism, and explain how it contributes to liver injury and liver tumorigenesis.