放射性药物分子的多功能化是药物设计中的一个非常重要的难题，传统的有机合成方法需要将功能模块共价连接到放射性药物分子上，增加了药物合成与筛选的难度。到目前为止，放射性标记的反义PNA已经被应用于癌症治疗与成像领域，并取得了不错的效果。在本研究课题中，在每条PNA单链末端引入不同的功能基团，利用PNA自组装技术，将其自组装为多功能放射性药物分子。该方法具有合成简单、易于多功能化等优点。

It's a great challenge for the multifunctionalization of the radiopharmaceutical drug. In the traditional organic synthesis, the functional modules could be covalently linked to the radiopharmaceutical molecules. This method undoubtely increases the difficulties for the drug synthesis and screening. Until now, labelled antisense PNA as radiopharmaceuticals has been used in the cancer therapy and imaging, and has achieved great progress. In this research, every PNA single strand was modified by functional modules. two or more PNA singles could be self-assemble into the multifunctional radiopharmaceuticals. This new strategy has many advantages, such as synthesis more easily, unlimited numbers of the functional modules and so on.