对肉蛋奶等动物源样品进行检测是保障食品安全的最后一道防线。检测技术成熟与否取决于样品前处理技术。现有的检测方法标准中，样品前处理过程占用了60%左右的时间，操作繁琐，待测物损失严重，且消耗大量有机溶剂。经合理设计合成的金属有机框架（Metal organic frameworks , MOFs）纳米材料具有较大的比表面积和孔隙率、结构和功能的可变性，具有较强的吸附β-激动剂等小分子化合物的作用；将其进行磁性修饰，再与单链抗体、纳米抗体等结构小、空间位阻效应低的广谱抗体偶联，具有特异性吸附结合待测物的功能；对MOFs纳米材料及其免疫磁性MOFs聚合物用扫描电镜、X射线衍射、傅里叶红外光谱、拉曼光谱等进行表征和功能鉴定；研究建立基于免疫磁性MOFs纳米材料为载体的“靶向吸附-定向吸附-磁性分离”的超高效样品前处理技术，为解决复杂动物源样品基质净化难题提供对策。

To detect meat, milk and other foods of animal origin is the last line of defense to ensure food safety. Whether the testing technology is mature or not depends on the pretreatment technology of the sample. In the existing detection method standard, the sample pretreatment process takes up about 60% of the time. The operation is cumbersome, and the loss of the tested sample is serious, and a large amount of organic solvents are consumed. The reasonable designed and synthesized metal organic frameworks (MOFs) nanomaterials had larger specific surface area and porosity, variable structure and function, with strong adsorption of beta agonists and other small molecular compounds. After magnetic modification, the MOFs were coupled with broad-spectrum antibody (single chain antibody, nanoantibody), with specific binding of targets. Characterization and functional identification of MOFs nanomaterials and their immunomagnetic conjugates by scanning electron microscope, X ray diffraction, infrared spectroscopy, Raman spectroscopy etc. Establishment of super efficiency sample pretreatment technology based on immune magnetic MOFs nanomaterials, was consisted of targeting adsorption, directional adsorption and magnetic separation, to provide solutions for purification of complex animal derived samples.