肝脏是一个具有强大再生能力的实质性器官。各种损伤刺激均可诱发肝再生。对其发生机制的认识有望为各类肝病患者提供新的治疗方式和手段。血小板是血液中的主要成分之一，广泛参与了凝血、炎症等诸多过程。瞬时电位势家族是细胞膜上重要的阳离子通道超家族，我们既往的研究发现瞬时电位势家族成员包括TRPV1和TRPM8在肝损伤时血小板的数量与功能均发生改变。本项目拟在已有研究工作基础上进一步探讨瞬时电位势家族成员在肝再生时对血小板的影响以及可能的发生机制，为认识肝再生进一步提供新的理论依据，为肝再生的治疗提供新的治疗手段和方法。本项目也是在既往国家自然科学基金项目上的系统性拓展和进一步的补充。

Liver is a organ that has a potential in regeneration mainly induced by inflammation and surgical resection. Deciphering on its mechamism can offer a novle modalities of its treatment. Platelet is one of the major components in blood that is involved in coagulation, inflammation and other pathophysiological process as well.Transient receptor potential is a superfamily of ion channel distributed on cell membrane.Our previous research revealed that TRPV1 and TRPM8 take effect on platelet in liver injury that include its volum and aggregation. The current porject is aimed at investigation on its mechanism of platelet in liver regeneration mediated by TRPV1 and TRPM8 in further so as to observe its possibility and feasibility on its treatment. It is a systemic supplement on previous work about transient receptor potential family in liver disease granted by NSFC.