近年来，四溴双酚A（TBBPA）在各种环境介质及人体生物样品中被广泛检出，关于TBBPA的毒性效应、人体暴露水平以及人体健康风险逐渐成为国内外研究热点。以往研究对TBBPA生物可给性这一暴露评价关键参数缺少关注，对于生物体内TBBPA的赋存形态（结合态/自由态）以及其对生物可给性的影响更是缺少研究。本研究拟建立实验室贝类养殖和TBBPA暴露系统，研究TBBPA在食用贝类中的富集规律；采用体外消化道模拟技术，模拟食用贝类在人体口腔、胃、肠中的消化过程，研究食用贝类中TBBPA的人体生物可给性，并分析TBBPA赋存形态对其生物有效性的影响及机制。本项目的开展，旨在为评估TBBPA的人体内暴露水平及其健康风险提供技术参数，并为进一步研究TBBPA人体中的吸收、降解和毒性作用等提供基础信息。

In recent years, Tetrabromobisphenol A (TBBPA) has been frequently detected in various environmental matrices and human biological samples. Their potential toxicity effects, human exposure and the potential health risk have gradually elicit particular concern. However, few studies have focused on the bioaccessibility of TBBPA in organisms, especially concerns over its free or bound fractions and the effects factors. In the present study, TBBPA exposure systems based on laboratory- contaminated shellfish will be established. TBBPA levels in shellfish will be investigated. In addition, the bioaccessibility of TBBPA will be investigated via an in vitro test by simulating the digestion process in the human gastrointestinal tract, and the effect factors will be analyzed. The results of this study will not only provide basic data to evaluate the TBBPA exposure for the human health protection, but also give essential support to research into the absorbtion, degradation, and improvement of our dietary structure.