非酒精性脂肪性肝病（NAFLD）疾病进展依次为单纯性脂肪肝、脂肪性肝炎(NASH)、肝纤维化和肝硬化，死亡率逐年增加。由于发病机制不明，目前尚无理想治疗药物。炎症反应是NAFLD疾病进展的恶化信号，近年来研究发现T淋巴细胞在NAFLD/NASH炎症反应中具有重要作用。红景天苷（SDS）被证实具有抗炎，抗氧化及维护体内免疫稳态，提高免疫力等诸多作用，然而SDS增强机体免疫，维护体内免疫稳态的显著益处在NAFLD/NASH进程中是否具有作用却知之甚少。本申请项目拟采用C57BL/6小鼠作为研究对象，蛋氨酸和胆碱不足（MCD）饮食构建NAFLD/NASH小鼠模型，给予SDS灌胃，持续4周，运用多种技术手段研究SDS通过调节T细胞免疫功能抑制NAFLD/NASH中炎症反应的作用；并通过体外细胞实验研究其分子信号途径。本研究为SDS作为治疗NAFLD药物的开发利用提供重要的理论依据。

Nonalcoholic fatty liver disease (NAFLD) is themost common chronic liver disease in the world, which canbe histologically categorized as simple fatty liver or as nonalcoholicsteatohepatitis(NASH). The latter pathological process candramatically confer increased risks of liver cirrhosis andhepatocellular carcinoma, which causing NAFLD mortality increased yearly. Inflammation is a deterioration signal in NAFLD process. Recent studies found thatT lymphocytes in NAFLD/NASH inflammation progression play an important role.Salidroside (SDS) has been demonstrated possess anti-inflammatory, maintain immune homeostasis, enhance body immunity capabilities andmany other effects. However, SDS benefits for body immune system wasnot investigate in NAFLD/NASH. This study intends to investigate whether SDS has the anti-inflammation effect on NAFLD/NASHvia regulating T-cell immune function. C57BL/6 mice withmethionine-choline deficient (MCD) diet were used to produce NAFLD/NASH mice model, and then dietary intake ofSDS for 4 weeks. After that investigate theSDS function in the inflammatory response in NAFLD/NASH mice, explore the underlying mechanism whether via SDS regulating T-cell immune function, and then searchrelevant signalingpathways in vitro. This study engagedto provide theoretical support for SDS as a potential drug for the treatment of NAFLD.