肾小球硬化是各种肾脏疾病进展的后期表现。在肾小球硬化的过程中会伴随着肾小球毛细血管的逐步丢失，恢复这些血管能改善肾单元功能。但是肾小球毛细血管完全损伤后的血管再生机制却没有研究涉及。因此我们选择具有强大肾脏再生能力的斑马鱼为模型，对肾小球毛细血管的再生机制进行了前期研究。我们发现再生过程中肾髓中游离的特定细胞类群聚集组成了肾小球毛细血管的胚芽，而后通过胚芽的增殖分化形成了肾小球毛细血管。这些游离的细胞可能为肾髓中的内皮祖细胞，这类细胞可能是通过CXCL12b/CXCR4信号途径被新生肾单元所招募。因此我们计划后期继续对肾小球毛细血管的再生过程以及具体的细胞来源，CXCL12b/CXCR4a信号途径对肾髓细胞招募的作用，肾小球毛细血管再生对肾脏再生以及肾小球硬化的作用等方面进行深入研究。阐明肾小球毛细血管的再生机制，将会为我们找到新的肾脏疾病治疗方法提供理论支持。

Glomerulosclerosis is the late symptom of various renal diseases. Glomerulosclerosisis always accompanied by a gradual loss of glomerular capillaries. Restoration of these capillaries can improve renal function. However, the mechanisms of vascular regeneration after complete lost of glomerular capillaries have not been studied. Therefore, we chose zebrafish as a model, which have strong renal regeneration ability, to study the regeneration mechanism of glomerular capillaries. We found that during the regeneration process one kind of free cell in renal medullary aggregation and composed of glomerular capillary buds. Then the glomerular capillaries will formed by the proliferation and differentiation of these buds. The free cells may be endothelial progenitor cells in the renal medulla. And these cells may be recruited by newly formed nephrons through the CXCL12b/CXCR4a signaling pathway. Therefore, we plan to continue to study the following issues. First，the regeneration process of glomerular capillaries and the cell source of regeneration. Second，the role of CXCL12b/CXCR4 signaling pathway in renal medullary cell recruitment. Third， effects of glomerular capillary regeneration on renal regeneration and Glomerulosclerosis. Our study will shed light on the regeneration mechanism of glomerular capillaries, which will provide theoretical support for the treatment of renal disease.