子宫内膜异位症致病因素复杂。APEX1是一个多功能蛋白，既参与DNA修复，也在氧化应激过程中发挥着重要的作用。我们前期研究发现APEX1的表达量在异位内膜组织中表达上升，且以腹膜型异位组织为最高。我们同时检测了9个候选miRNAs在异位子宫内膜中的表达，发现miR-24和miR-196b与APEX1的表达存在显著的相关性。我们拟研究：（1）检测APEX1在不同类型子宫内膜异位组织中的表达量，建立APEX1与子宫内膜异位分型之间的关系。（2）检测异位组织中差异表达的miRNAs，分析APEX1与miRNAs表达的相关性，建立APEX1与miRNAs表达量在子宫内膜异位组织中的关系。（3）鉴定差异miRNAs的靶基因，并在细胞水平验证其生物学功能，阐述APEX1与子宫内膜异位发生、发展及癌变的关系。以揭示APEX1在子宫内膜异位发生、发展中的作用。

The exact pathogenesis of endometriosis is complecated. APEX1 is a multi-function protein involved in both DNA repair and oxidative stress response related pathways. Our previous study indicated that the expression of APEX1 is higher endometriosis tissue samples, and extremely high in the samples from patients with peritoneal endometriosis. We also examined the expression of 9 candidate miRNAs and find significant positive correlations between miR-24, miR-196b and APEX1. We intend to study the function of APEX1 from the following three aspects. (1) Detect the expression of APEX1 in different types of endometriosis and establish the relationship between APEX1 and endometriosis subtypes. (2) Examine differentially expressed miRNAs in ectopic tissues and analyze the correlation between APEX1 and miRNAs, and subsequently establish the relationship between the expression of APEX1 and miRNAs in endometriotic tissues. (3) Identify the target genes of candidate miRNAs and investigate their biological functions in vitro. Partially unveil the relationship between APEX1 and the occurrence, development and cancerization of endometriosis. Depending on the above studies, we will reveal the role of APEX1 in the occurrence and development of endometriosis, providing a tool for clinical classification and individualized medical treatment.