三维超声自动全局寻优及血管树自动图像融合优化肝癌消融计划制定与实施的研究

消融是肝癌最常用的治疗方法之一，消融计划的合理制定及实施是保证疗效的关键。本项目在前期构建计算机软件的基础上，拟在体外模型和肝癌动物模型上使用三维超声全局寻优方法自动制定穿刺布针方案，以提高消融计划制定的精确性和效率，同时减少肝内、肝周重要结构的损伤；使用三维超声血管树自动图像融合协助穿刺消融，以提高计划实施的准确性并减少操作时间。通过探讨上述方法的可行性、准确性、影响因素及最佳使用条件，期望为临床提供一种对肝癌消融计划制定与实施进行优化的新方法，达到精确、安全、快捷消融肝癌的目的，具有较大的理论研究意义及重要的临床应用价值。

AAblation is an important treatment for liver cancer, constitution and actualization of the ablation planning are the key factors to satisfactory treatment results. On the basis of previously constructed software, we intend to increase the accuracy and efficiency of ablation planning constitution and reduce the ingury to the important structures in and around the liver using 3D ultrasound automatic global optimization in phantom and animal model. Then we try to enhance the precision of the actualization of the ablation planning and shorten the time spent using automatic 3D ultrasound image fusion by vessel tree. The feasibility, accuracy, influent factors and the best applied condition are evaluated in order to optimize constitution and actualization of the ablation planning which lead to precise, accurate and quick ablation of liver cancer.