聚集诱导发光功能化的柔性金属-有机骨架物在小分子传感中的应用研究

新型聚集诱导发光聚集体的研究是揭示聚集诱导发光机理、建立新颖分析方法的重要途径。现阶段聚集诱导发光的研究对象主要集中于无序、封闭的聚集体，不利于聚集诱导发光的机理研究及其进一步应用。开发新型“开放式”聚集诱导发光聚集体对于研究聚集诱导发光机理及拓展其应用具有重要意义。本项目以柔性金属-有机骨架物作为聚集诱导发光分子的聚集基质，开发具有开放、可逆、规则结构的新型聚集诱导发光聚集体。以此类新型聚集诱导发光聚集体的光学性质为研究对象，研究小分子作为外来刺激物，改变金属-有机骨架物的空间结构，揭示空间结构变化对聚集诱导发光分子光学性质的影响；研究聚集诱导发光分子在金属-有机骨架物开放式孔道中与外来客体小分子的荧光能量转移、电子转移等作用。基于此类新型聚集体与小分子的相互作用，建立高选择性、高灵敏度的小分子分析传感方法。项目的研究有望深入探讨聚集诱导发光机理，拓展聚集诱导发光的应用领域。

Research on new type aggregation induced emission　(AIE) aggregates is an important way to reveal the mechanism of AIE and build novel analytical method. In nowadays, the most research on AIE are focused on the disorderly closed aggregates, which is not benefit for the study on AIE mechanism and further application. The study on open AIE system is an important way to discover the mechanism of AIE and expand the related applications. In this project, we will focus on the optical property of AIE molecules in flexible metal-organic frameworks (MOFs) substrate. After chemical modification, the AIE molecules can aggregate in flexible MOFs by an orderly and controllable route. And then we can get a new type AIE aggregate with open, reversible and ordered structure. The influence of MOFs’ spatial structure on optical property of AIE molecules can be studied by stimulated with some small molecules. MOFs’ open structure is good for studying the chemical interaction ( such as fluorescent energy transfer or electron transfer process) between AIE molecules with small molecules in MOFs’ channels. Some high selective and sensitive fluorescent sensors can be built based on the interactions between the new type aggregates with small molecules. This project can deeply investigate the mechanism of AIE and expand related applications.