神经源性OAB严重影响患者生活质量，且其治疗是迄今尚未解决的医学难题。我们既往研究发现艾灸能抑制膀胱传入神经C纤维的过度活动。最新研究显示：膀胱逼尿肌兴奋性受自主神经和体神经双重支配，调控机制复杂。膀胱ICC及骶髓排尿中枢c-fos基因在调控逼尿肌异常兴奋中有着核心作用。我们提出科学假说：艾灸神阙穴通过“脐”-“骶”-“膀胱”圆周弧理论改善神经源性OAB症状。因此，本课题采用免疫组化、Western Blot技术和神经电生理技术，从膀胱ICC细胞、相应骶髓节段背根节中HCN4通道蛋白及骶髓排尿中枢c-fos基因表达变化阐释艾灸神阙穴治疗神经源性OAB的分子生物学机制；从膀胱NGF高表达与膀胱C传入纤维兴奋性增高关系阐释艾灸神阙穴治疗神经源性OAB的神经电生理机制。为艾灸神阙穴通过“脐”-“骶”-“膀胱”圆周弧理论改善神经源性OAB症状提供实验依据，为临床治疗神经源性膀胱开辟新的途径。

Neurogenic OAB seriously affects the quality of life of the patient, and its treatment is a medical problem that has not been solved yet. Our previous study found that moxibustion could inhibit the overactivity of the C fibers of the bladder afferent nerve. The latest research shows that the excitability of the detrusor is controlled by the dual control of the autonomic and the somatic nerves, and the regulatory mechanism is complex. The c-fos gene in the bladder ICC and the sacromedullary micturition center plays a core role in regulating detrusor excitability. We put forward the scientific hypothesis: the moxibustion of Shenque through the "umbilical" - "sacral" - "bladder" circular arc theory to improve neuropathic symptoms of OAB. Therefore, this topic by immunohistochemistry and Western Blot technique and neural electrophysiological techniques, from the molecular biology mechanism of bladder ICC cell, the corresponding sacral segment of dorsal root section HCN4 channel protein and sacral micturition center c-fos gene expression interpretation of Shenque point moxibustion treatment of neurogenic bladder from OAB; NGF high expression of nerve the electrophysiological mechanism of excitatory fibers increased to explain the relationship between Shenque point moxibustion for treatment of neurogenic bladder afferent and OAB C. For the moxibustion of Shenque through "umbilical cord" - "sacral" - "bladder" circular arc theory to improve neuropathic symptoms of OAB and provide experimental basis, a new method for the clinical treatment of neurogenic bladder.