急性心肌梗死的病生理基础为：冠状动脉粥样硬化病变导致冠脉管腔狭窄的基础上，脂质斑块破裂等因素引起急进的高血栓负荷及炎症反应。使冠脉管腔严重狭窄或闭塞引起心肌缺血缺氧性改变。 我们已经证实血清硫脑苷脂密切参与了动脉粥样硬化病变、血栓形成及炎症反应过程，并与人类冠心病密切相关。并提出假说：血清硫脑苷脂可能为人类心血管病的新奇生物标记物。但其中的具体变化及作用机制尚有待进一步探讨。因此，我们采用脂类组学软电离质谱技术分析测定急性心肌梗死时血清硫脑苷脂脂质图谱的特征性变化并探索其发生的机制。从而为急性心肌梗死的诊断、评估继传统的心电学、血清酶学方法后，可能开创出全新的脂类组学方法。

The pathological basis of acute myocardial infarction : On the basis of coronary stenosis result from atherosclerotic lesions, lipid plaque rupture caused sharp thrombus loading and inflammatory reaction，which result in severe restenosis or occlusion of the coronary lumen，thus myocardial ischemic necrosis. We have found that serum sulfatides were closely involved in the atherosclerotic lesions, thrombosis, and inflammatory reaction, which were closely related with human coronary heart disease. We have proposed the hypothesis: serum sulfatide may be a novel biomarker of human cardiovascular disease. However, the characteristic changes and mechanism of serum sulfatide in acute myocardial infarction remains to be unclear. In this study: We will explore that the characteristic changes and mechanism of serum sulfatides in acute myocardial infarction by lipidomics laser desorption ionization-time-of-flight mass spectrometric technique，which maybe create a novel lipidomics method in diagnosing and evaluating acute myocardial infarction in addition to traditional electrocardiologic and serum enzymologic method.