Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia.
Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia.
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家族性高胆固醇血症患者血清硫苷脂与颈动脉内膜中层厚度的相关性
DOI：
10.1007/s10719-014-9555-5
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发表时间：
2014-11
影响因子：
3
通讯作者：
Hu, Rui
中科院分区：
文献类型：
--
作者：
Li, Gang;Hu, Rui
在人类家族性高胆固醇血症动物模型中，硫苷脂与动脉粥样硬化之间存在正相关性。颈动脉内膜中层厚度（IMT）被认为是人类动脉粥样硬化的标志物。我们研究了杂合子家族性高胆固醇血症（FH）患者中硫苷脂与颈动脉IMT的关系。我们的研究招募了35名遗传学证实的FH杂合子患者和34名健康对照。我们测量了血清硫脂水平、颈动脉IMT和传统的心血管危险因素，包括肥胖参数、血压、空腹血糖和血脂。与对照组相比，杂合子FH患者血清硫脂、总胆固醇、低密度脂蛋白胆固醇和颈动脉IMT显著升高。单因素分析显示，FH患者血清硫脂水平与颈动脉IMT显著相关。多元线性回归分析显示，血清硫苷脂是FH患者颈动脉IMT的唯一独立预测因子。杂合子FH患者的颈动脉IMT显着升高，血清硫苷脂水平与动脉粥样硬化进展独立相关。（R：0.720，R2：0.503，p < 0.001）。
There is a positive association between sulfatide and atherosclerosis in an animal model for human familial hypercholesterolemia. Carotid intima–media thickness (IMT) is thought to be a marker of atherosclerosis in humans. We investigated the relationship between sulfatide and carotid IMT in heterozygous familial hypercholesterolemia (FH) patients. Thirty-five genetically-verified heterozygous patients with FH and 34 healthy controls were recruited into our study. We measured serum sulfatide levels, the carotid IMT, and conventional cardiovascular risk factors including obesity parameters, blood pressure, fasting blood glucose, and lipid profiles. Subjects with heterozygous FH had significantly elevated serum sulfatide, elevated total cholesterol, low-density lipoprotein cholesterol, and increased carotid IMT compared with control subjects. In patients with FH, univariate analysis showed that serum sulfatide was significantly correlated with carotid IMT. Multiple linear regression analysis indicated that serum sulfatide was the only independent predictor of carotid IMT in patients with FH. Patients with heterozygous FH had significantly higher carotid IMT and the level of serum sulfatide was independently associated with atherosclerotic progression. (R: 0.720, R2: 0.503, p < 0.001).
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影响因子：
2.7
作者：
HARA, A;TAKETOMI, T
通讯作者：
TAKETOMI, T
影响因子：
37.8
作者：
März, W;Scharnagl, H;Winkelmann, BR
通讯作者：
Winkelmann, BR
影响因子：
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作者：
Nolting, PRWD;de Groot, E;Kastelein, JJP
通讯作者：
Kastelein, JJP
影响因子：
39.2
作者：
Hodis, HN;Mack, WJ;Azen, SP
通讯作者：
Azen, SP
影响因子：
5.3
作者：
Inoue, T.;Taguchi, I.;Node, K.
通讯作者：
Node, K.