超宽谱电磁脉冲协助药物通过血脑屏障及在脑肿瘤治疗中的应用研究

血脑屏障（BBB）的存在极大的限制了大分子药物进入脑组织，是中枢神经系统疾病治疗亟待解决的一个关键问题。如：恶性脑胶质瘤治疗效果差的主要原因之一是由于BBB的存在限制了化疗药物进入肿瘤组织。我们前期研究发现，超宽谱电磁脉冲（UWB-EMP）可致啮齿类动物BBB可逆性开放，促进化疗药物进入脑组织，提高脑胶质瘤治疗效果。本项目拟以犬、小香猪等大动物为实验对象，对UWB-EMP 致BBB 开放的各项物理参数进行优化，扩大筛选在UWB-EMP协助下可通过BBB的药物，并且同时研究其定向聚焦辐照技术，最后在脑肿瘤荷瘤动物模型和脑肿瘤病人志愿者身上对UWB-EMP治疗脑肿瘤的效果进行验证，明确其协助化疗药物穿过BBB 治疗脑肿瘤的有效性以及对脑肿瘤的直接杀伤作用，为将来临床上对脑肿瘤的个体化治疗提供理论和实验依据。本项目的实施有望为脑肿瘤患者提供一项全新的具有自主知识产权的治疗技术和手段。

It is wll known that most of large molecules drug cannot go into brain tissues because of the existence of blood brain barrier (BBB), which is an important problem to solve if we want to increase the therapeutic effect of central nervous system(CNS) diseases. For example, Malignant glioma is a common and severe primary brain tumor with a high recurrence rate and an extremely high mortality rate within 2 years of diagnosis, even when surgical, radiological, and chemotherapeutic interventions are applied.Intravenously administered drugs have limited use because of the poor blood-brain barrier (BBB)penetration. The need for effective BBB drug-targeting systems is obvious and urgent Previously, we found that ultra-wide band electromagnetic pulse (UWB-EMP) induced rodent BBB openning and increased drug delivery to brain tumors, which improved the treatment effectiveness of brain glioma. In this study, big animals such as dogs and pigs will be used to optimize the physical parameters of UWB-EMP which can open BBB. Meanwhile, the directional focus exposure technology will be investigated. Finally, the effectivity of UWB-EMP assists he motherapeutics to cross BBB to treat brain tumors and the direct lethal effect on killing brain tumors will be studied in order to provide theory and experimental data for the clinical probation of this UWB-EMP apparatus. This noninvasive technique promises to provide a brand new treatment technic and method for brain tumor with independent intellectual property right.