中药提取物是多成分的有效集合体，其复杂的整体特征如成分组成、物理化学特性、生物医学信息等都难于精确表征和预测。为此，我们提出：中药提取物可分为基本活性物质与伴生物质，后者种类与数量的不同使前者形成具有差异性的物理化学性质，影响其吸收等体内过程，但影响机理以及如何表征尚不清楚。项目组基于中药提取物生物药剂学特征与其物理化学性质的相关性开展研究，主要以三七总皂苷提取物为研究对象，采用膜分离等技术制备了不同伴生物三七皂苷提取物，继而测定了物理化学参数与药动学参数，运用遗传算法等手段建立二者相关性数学模型，初步探索了物理化学性质与吸收的相关性。本项目拟在此基础上，将深入研究影响皂苷吸收的主要物理化学参数及其机理；揭示较为理想生物药剂学特征的皂苷提取物所具有的物理化学性质。其研究引入中药提取物的生物药剂学特性，通过其物理化学参数的表征进行宏观描述及预测，对探索建立新的中药提取分离评价体系有重要意义。

Chinese traditional medicine extract is an effective aggregation of multiple components,and its overall characteristics such as complex ingredients, physical and chemical properties, biomedical information are difficult to demonstrate accurately and predict. Therefore, we propose: Chinese traditional medicine extract can be divided into two categories, namely basic active substances and accompanying material. Difference of categories and quantity of the later cause the chemical and physical property which making the diversity of former, impacting its internal process, such as absorption, but it is still unclear how the impacting mechanism and characterization work.Based on the interdependency of biomedical character of Chinese traditional medicine extract and its chemical and physical property, program team develop an research, mainly using root of pseudo-ginseng total saponin extracts as research object. Through technology as membrane separation to prepare different different saponins extract, and thus determine physical and chemical parameters and the pharmacokinetic parameters. Method such as the genetic algorithm is applied to build the correlation mathematical model, preliminary to explore the correlation of the chemical and physical properties and absorption. The program intends to, based on the obtained result, investigate deeply on main physical and chemical parameters which influence Saponins absorption and its mechanism; to reveal ideal bio-pharmaceutical characteristics of saponins extract with the physical and chemical properties. The research includes bio-pharmaceutical characteristics of traditional Chinese medicine extract, through its characterization of physical and chemical parameters for macroscopic description and prediction, and it has important theoretical significance on exploring to establish Chinese medicine extract evaluation technology.