中药材中重金属超标已成为用药安全性的关键问题。目前中药材中重金属的研究缺少元素不同形态和价态的分析；忽视了重金属元素在药用植物生长过程中的各器官的分布、迁移和富集。本项目选择2010年版《中国药典》所收载的25种常用中药材，采用蔬菜、花卉中重金属研究的水培方法和盆栽试验，研究药用植物幼苗中重金属(铬、镉、汞、铅、砷和铜)的亚细胞分布、生理特征的变化、根系的活力和根的细胞形态特点；研究重金属元素在药用植物的根、茎、叶、花、果实、种子等器官的迁移、富集和化学形态。采用Tessier的五步分级法研究重金属元素在药用植物各器官的化学形态，采用HPLC-ICP-MS测定不同价态的重金属元素，从而建立多维的药用植物重金属分析体系。通过药用植物中重金属总量、分布、迁移、富集、形态和价态之间的关系，建立一个科学、完善被国际认可的中药材重金属元素的限量控制标准，也为重金属污染区的植物修复提供理论依据。

Superstandard of heavy metals in traditional Chinese medicines has become the key problems of drug safety.The research on traditional Chinese medicines of heavy metals ignored the chemical speciation analysis and valence state analysis of elements, and ignored the organ distribution,migratiom and accumulation of heavy metals in various organs of the growth process. The 25 kinds of commonly used medicine documented in 2010 edition of "Chinese Pharmacopoeia" will be chosen as a target traditional Chinese medicines, The different concentrations of heavy metal elements (chrome, cadmium, mercury, lead, arsenic and copper) in the cultural system will be studied to reveal the accumulation, subcellular distribution, the change of physiological characteristics of seedling, the vitality and cell morphology of the root and chemical forms of heavy metal elements in medical plants using hydroponics technique.The migratiom and chemical speciation of the heavy metal in medicinal plant different organs (root, stem, leave, flower, fruit, seed) will be analyzed using pot experiment. The distribution, migration, speciation analysis and valence state of heavy metals in various organs using the sequential extraction procedure by Tessier and HPLC-ICP-MS.A multi-dimensional analysis system of heavy metal will be established to understand the relationship between the total metal,migration,speciation and valence state in medical plants, and to provide theoretical basis for the phytoremediation of heavy metal pollution of traditional Chinese medicines.