探寻桥连高脂肥胖和固有免疫调控的关键节点开关

代谢调节和固有免疫是个体生命中十分重要的两个过程。代谢紊乱往往伴随着机体固有免疫应答的变化，但变化规律，两者之间的协调关系以及关键节点开关未知。本项目拟（1）重点总结高脂肥胖（western diet/high fat diet）所造成的代谢紊乱过程中固有免疫炎症应答改变的变化规律；（2）利用果蝇的遗传筛选优势，在肥胖/正常果蝇的RNA-Seq差异基因中，寻找同时应答于高脂肥胖诱导以及参与固有免疫调节的节点因子；（3）挖掘代谢紊乱进程中免疫学应答与调控转变的分子机制，并试图总结出“代谢-免疫”转换和平衡的普遍规律，为今后潜在的治疗策略提供必要的理论支持。

Metabolic disorder is often a cause of innate immune irregularities and associates with chronic inflammation. However, how “metabolic-innate immune” coordination and the characterization of “metabolic-innate immune” switches remain poorly understood. Herein, we propose 1) to specially summarize how high fat diet (western diet) induced obesity disturbs innate immune homeostasis; 2) to genetic screening innate immune regulators from HFD/NFD RNA-Seq differential genes in Drosophila; 3) to investigate the mechanisms of “metabolic-innate immune” homeostasis. This project will surely extend our knowledge to potential therapy in the future.