随着生活方式改变，代谢性高血压（MH）已为高血压主体，防治需求大。饮食不节致短链脂肪酸（SCFAs）含量降低，使其通过G蛋白偶联受体（GPCRs）介导的胃肠功能、代谢和血压等改善作用减弱，而易致MH。铁皮石斛改善胃肠功能、降血压和调节代谢异常等作用确切，但其通过增加SCFAs而发挥抗MH的作用及机制尚不明确。我们认为铁皮石斛超微粉（DOP）“厚肠胃”改善胃肠功能，从而改善“肥甘醇酒”致MH，其机制可能与增强“SCFAs-肠道菌群-肠”互作，增加肠源性SCFAs，激活SCFAs-GPCR43/41有关。拟采用过食“肥甘醇酒”致MH大鼠，在以SCFAs为核心的DOP抗MH整体药效评价的基础上；从SCFAs生成、转运角度阐述DOP增加SCFAs含量；分析激活SCFAs-GPCR43与改善糖脂代谢的相关性；并主要从激活SCFAs-GPCR41，阐明DOP降压机制。为防治MH的机理研究提供新切入点。

With the change of lifestyle, the metabolic hypertension (MH) has become the principal part of hypertension, and its prevention and treatment demand is great. Improper diet could cause the decrease of gut derived short chain fatty acids (SCFAs), which could active G protein coupled receptors (GPCRs), therfore, weakened the improvement of gastrointestinal function, metabolism and blood pressure, which easily lead to the development of MH. Dendrobium officinale is a commonly used "Strengthened enterogastric function" medicine, which had the exact effect on improvement of gastrointestinal function, lowering blood pressure, and improving metabolic abnormalities, etc, but wheather the effect and mechanism of Dendrobium officinale on anti-metabolic hypertension based on improvment of SCFAs are not clear. Dendrobium officinale ultramicro powder (DOP) is regarded to improve the hypertension may be related to improve the gastrointestinal function, increase the intestinal SCFAs, activate the GPCR43/41-mediated glycolipid metabolism and vascular protective effect. Prepare MH rat model by feeding with alcohol and high fat&sugar diet. Meanwhile, based on focusing the DOP effect on increasing its SCFAs content and improving gastrointestinal pathophysiology, glucose and lipid metabolism and blood pressure. From the point of produce of SCFAs and transporting into blood to explain mechanism of DOP on increase the intestinal SCFAs content, with analysis of the correlation between the activation of SCFAs-GPCR43 and the improvement of glycolipid metabolism, and mainly from the activation of SCFAs-GPCR41 pathway to clarify DOP antihypertensive mechanism. This study provides a new entry point for study of prevention mechanism and treatment of metabolic hypertension.